Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults.
Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults.
复制标题
负面年龄刻板印象与加速细胞衰老之间的关联：来自两个老年人群体的证据。
DOI：
10.1111/jgs.14452
复制
发表时间：
2016
影响因子：
6.3
通讯作者：
Levy,BeccaR
中科院分区：
文献类型：
--
作者：
Pietrzak,RobertH;Zhu,Yong;Slade,MartinD;Qi,Qiaochu;Krystal,JohnH;Southwick,StevenM;Levy,BeccaR
Negative age stereotypes, which are defined as disparaging beliefs about older persons as a category, have been linked to increased rates of physical and cognitive decline, and mortality in older adults. 1–5 To date, however, no known study has evaluated whether these stereotypes are associated with shorter telomere length, a marker of accelerated cellular aging that provides a cumulative measure of cell divisions, and exposures to genotoxic and cytotoxic processes such as oxidation and inflammation. 6 Characterization of this association may provide insight into a possible molecular mechanism linking negative age stereotypes to accelerated functional decline and mortality, and inform prevention and treatment strategies designed to mitigate functional decline and preserve quality of life in older persons.We evaluated the hypothesis that negative age stereotypes would be associated with shorter telomere length in two diverse cohorts of older adults at elevated risk of stress compared to their same-aged peers: older US military veterans, who have higher rates of exposure to traumatic life events such as combat; and older adults who recently experienced an acute myocardial infarction (AMI).
