Osteoprotegerin levels in peri-implant crevicular fluid
Osteoprotegerin levels in peri-implant crevicular fluid
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DOI：
10.1111/j.1600-0501.2007.01463.x
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发表时间：
2008-03-01
影响因子：
4.3
通讯作者：
Kutukculer, Necil
中科院分区：
文献类型：
--
作者：
Arikan, Fatih;Buduneli, Nurcan;Kutukculer, Necil
目的：评估骨内牙种植体的龈沟液中可溶性核因子κB配体受体激活剂（sRANKL）和骨保护素（OPG）的水平。方法：对39名患者的86个种植体进行了评估。所有患者均在检查前接受了至少 16 个月植入并至少 12 个月加载的牙根型种植体治疗。从种植体的颊侧和舌侧获取种植体周围裂隙液 (PICF) 样本。在每个种植体的四个部位记录修正的牙菌斑指数、探诊深度、牙龈指数和探诊出血 (BOP)。通过 ELISA 分析 sRANKL 和 OPG 的 PICF 水平。利用Spearman相关性将生化数据和临床参数联系起来。结果：sRANKL的PICF水平与临床参数或OPG水平没有显示出显着相关性。 OPG总量与PICF体积、牙龈指数和BOP呈正相关（P < 0.05），与包装年数呈负相关（P < 0.05）。结论：本初步研究结果表明，OPG水平值得进一步研究，作为评估牙种植体周围组织健康状况的可能标志，而sRANKL水平则不然。更大规模的研究，特别是种植体周围炎病例，可能会对这个问题有更多的了解。
Aims: To evaluate the levels of soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) and osteoprotegerin (OPG) in crevicular fluid of endosseous dental implants.Methods: Eighty-six implants in 39 patients were evaluated. All patients were treated with root-type implants placed at least 16 months and loaded at least 12 months before the examination. Peri-implant crevicular fluid (PICF) samples were obtained from buccal and lingual aspects of implants. Modified plaque index, probing depth, gingival index, and bleeding on probing (BOP) were recorded at four sites per implant. PICF levels of sRANKL and OPG were analysed by ELISA. Spearman's correlations were utilised to relate biochemical data and clinical parameters.Results: The PICF level of sRANKL did not show significant correlation with the clinical parameters or the OPG level. The total amount of OPG was positively correlated with PICF volume, gingival index, and BOP (P < 0.05) and negatively correlated with pack years (P < 0.05).Conclusion: The findings of this preliminary study suggest that the crevicular fluid level of OPG deserves further investigation as a possible marker to evaluate the health status of surrounding tissues of dental implants, as this was not the case for the sRANKL level. Larger scale studies, particularly in peri-implantitis cases, may shed more light on this subject.