Lower urinary tract symptoms and erectile dysfunction: Co-morbidity or typical "aging male" symptoms? Results of the "Cologne male survey
Lower urinary tract symptoms and erectile dysfunction: Co-morbidity or typical "aging male" symptoms? Results of the "Cologne male survey
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DOI：
10.1016/s0302-2838(03)00358-0
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发表时间：
2003-11-01
期刊：
影响因子：
23.4
通讯作者：
Engelmann, UH
中科院分区：
文献类型：
--
作者：
Braun, MH;Sommer, F;Engelmann, UH
目的：由于工业化国家的人口发展，与年龄相关的疾病变得越来越重要。从许多流行病学研究中我们知道，良性前列腺增生（BPH）和勃起功能丧失（=勃起功能障碍或艾德）的患病率随着年龄的增长而增加。这两种疾病是相关的还是独立的？研究方法：我们邮寄我们新开发的和验证的男性勃起功能障碍（KEED）的问卷，以及一组有关排尿问题（IPSS）的问题，一个代表性的人口样本的8000名男子从30至80岁居住在城市的科隆。结果：答复包括4489可评估的答复（56.1%）。不同年龄组的应答率从41%到61%不等。回答问题的男性的平均年龄为51.8岁。艾德的总患病率为19.2%（n = 862），与年龄相关的急剧增加，从2%增加到53%。此外，31.2%（n = 1957）的男性抱怨下尿路症状（LUTS），患病率和强度随着年龄的增长而增加。有趣的是，在艾德和排尿问题之间发现了高共病率。患有艾德的男性中LUTS的患病率约为72.2%（n = 621），而正常勃起的男性中为37.7%（1367）。比值比为2.11。三因素分析显示，下尿路症状的发生是艾德发展的一个与年龄无关的危险因素（p < 0.001）。结论：尽管下尿路症状与艾德之间的发病关系尚未完全清楚，但我们必须假设这两种典型症状复合体在老年男性中存在直接联系。(C)2003 Elsevier B.V.保留所有权利。
Objectives: Due to demographic developments in industrial nations, age-correlated diseases are becoming more important. From many epidemiological studies we know that the prevalence of benign prostatic hyperplasia (BPH) and the loss of erectile function (= erectile dysfunction or ED) increase with advancing age. Are these two illnesses related or/and independent?Methods: We mailed our newly developed and validated questionnaire on male erectile dysfunction (KEED), as well as a set of questions pertaining to voiding problems (IPSS), to a representative population sample of 8000 men from 30 to 80 years of age residing in the city of Cologne.Results: The responses included 4489 evaluable replies (56.1 %). The response rates in the different age groups ranged from 41 to 61 %. The mean age of the men who answered was 51.8 years. The overall prevalence of ED was 19.2% (n = 862), with a steep age-related increase from 2 to 53%. Furthermore, 31.2% (n = 1957) of all men complained of lower urinary tract symptoms (LUTS), the prevalence and the intensity of which increased with age. Interestingly, a high co-morbidity was found between ED and voiding problems. Prevalence of LUTS in men suffering from ED was about 72.2% (n = 621) vs. 37.7% (1367) in men with normal erections. The odds ratio was evaluated with 2.11. The trivariate analysis showed that the occurrence of LUTS can be considered as an age-independent risk factor for the development of ED (p < 0.001).Conclusions: Even though the pathogenetic relationship between LUTS and ED is not yet completely understood, one has to postulate a direct association between these two typical symptom complexes in the aging male. (C) 2003 Elsevier B.V. All rights reserved.