Solvolysis of Formylphenyl Esters by a Bifunctional Peptide Catalyst
Solvolysis of Formylphenyl Esters by a Bifunctional Peptide Catalyst
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DOI：
10.1246/cl.151154
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发表时间：
2016-03-05
影响因子：
1.6
通讯作者：
Kudo, Kazuaki
中科院分区：
文献类型：
--
作者：
Akagawa, Kengo;Kudo, Kazuaki
建立了一种以甲酰基苯酯和双功能肽为催化剂的人工水解体系。控制脯氨酸氨基和组氨酸咪唑两个功能基团在肽中的空间位置对水解反应效率有重要影响。该体系在动力学拆分中的应用被证明是可行的。
An artificial hydrolytic system using a formylphenyl ester and a bifunctional peptide catalyst was developed. Controlling the spatial positions of the two functional groups, the amino group of proline and the imidazole of histidine in the peptide, was important for the reaction efficiency of hydrolysis. The application of this system to kinetic resolution was shown to be plausible.