Hepatitis E virus infection in wild mongooses of Okinawa, Japan: Demonstration of anti-HEV antibodies and a full-genome nucleotide sequence
Hepatitis E virus infection in wild mongooses of Okinawa, Japan: Demonstration of anti-HEV antibodies and a full-genome nucleotide sequence
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DOI：
10.1016/j.hepres.2005.10.010
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发表时间：
2006-03-01
影响因子：
4.2
通讯作者：
Mishiro, S
中科院分区：
文献类型：
--
作者：
Nakamura, M;Takahashi, K;Mishiro, S
戊型肝炎病毒（HEV）是一种单链RNA病毒，不仅从人身上，而且从各种动物身上也发现了这种病毒。在这里，我们报告我们的研究结果表明，猫鼬应添加到HEV的水库动物名单。我们在日本冲绳检查了100只猫鼬，其中21只被认为是抗-HEV抗体阳性，其中1只明确为HEV RNA阳性。全基因组测序的戊型肝炎病毒分离株显示，它分离到一个独特的亚组内的基因型III。有趣的是，这种猫鼬菌株与先前报道的来自冲绳的猪分离株密切相关，暗示了这些动物之间种间传播的可能性。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Hepatitis E virus (HEV), a single-strand RNA virus, has been recovered not only from human beings but also from various species of animals. Here we report our results suggesting that mongoose should be added to the list of reservoir animals of HEV. Of 100 mongooses we examined in Okinawa, Japan, 21 were thought to be positive for anti-HEV antibodies, among which one was definitely positive for HEV RNA. Full-genome sequencing of the HEV isolate revealed that it segregates to a unique subgroup within genotype III. Interestingly, this mongoose strain was closely related to a swine isolate previously reported from Okinawa, implicating the possibility of interspecies transmission between these animals. (c) 2005 Elsevier Ireland Ltd. All rights reserved.