Deprescribing Trials: Methods to Reduce Polypharmacy and the Impact on Prescribing and Clinical Outcomes
Deprescribing Trials: Methods to Reduce Polypharmacy and the Impact on Prescribing and Clinical Outcomes
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DOI：
10.1016/j.cger.2012.01.006
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发表时间：
2012-05-01
影响因子：
3.3
通讯作者：
Hilmer, Sarah N.
中科院分区：
文献类型：
--
作者：
Gnjidic, Danijela;Le Couteur, David G.;Hilmer, Sarah N.
虽然使用多种药物或多药治疗可能会对一些患有多种疾病的老年人产生积极的结果，但越来越多的证据表明，它与不良事件风险增加有关。因此，合理停药可能是适当的临床决定，并且可能会给一些接受多种药物治疗的老年人带来显着的临床和功能益处。本临床综述旨在强调老年人中用于减少多重用药的各种干预措施的有效性的证据，以及对处方和临床结果的影响。
While use of multiple medications or polypharmacy might generate positive outcomes for some older adults with multiple diseases, there is increasing evidence that it is associated with increased risks of adverse events. Therefore, rational withdrawal of medications may be the appropriate clinical decision and may result in significant clinical and functional benefits in some older people exposed to polypharmacy. This clinical review aims to highlight the evidence in older adults for the effectiveness of various types of interventions used to reduce polypharmacy, and the impact on prescribing and clinical outcomes.