Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder
Gastrointestinal symptoms and behavioral problems in preschoolers with Autism Spectrum Disorder
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DOI：
10.1016/j.dld.2015.11.026
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发表时间：
2016-03-01
影响因子：
4.5
通讯作者：
Muratori, Filippo
中科院分区：
文献类型：
--
作者：
Fulceri, Francesca;Morelli, Mariangela;Muratori, Filippo
背景资料：自闭症谱系障碍（ASD）患儿常出现胃肠道（GI）症状，GI合并症对ASD行为问题的影响已被推测，目的：探讨ASD患儿和正常发育（TD）儿童GI症状的类型和患病率，并探讨其与行为问题的可能关系。具体而言，评估了四组儿童：患有GI症状的ASD个体（ASD/GI+），没有GI症状的ASD受试者（ASD/GI-），TD同龄人（TD/GI+）和没有（TD/GI-）GI症状。采用儿童行为检查表11/2- 5对父母的行为问题和胃肠道症状进行评估。结果：ASD患者中有胃肠道症状的比例（37.4%）显著高于TD患者（14.8%）。“便秘”和“不吃”是ASD和TD组中最常见的GI症状，但在ASD患者中被评估为更严重。ASD/GI+儿童比ASD/GI-个体有更多的焦虑问题、躯体抱怨、外化和总体问题。TD/GI+并没有表现出更多的行为问题比TD/GI-。结论：发展的循证指南，以确定在ASD学龄前儿童的GI问题是必要的。应准确评估胃肠功能，特别是在ASD儿童焦虑和/或外化行为问题。(C)2015 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background: Gastrointestinal (GI) symptoms are frequently reported in children with Autism Spectrum Disorder (ASD), and an impact of GI comorbidity on ASD behavioral problems has been hypothesized.Aims: To explore the type and the prevalence of GI symptoms in ASD patients and typical development (TD) controls, and to investigate their possible association with behavioral problems.Methods: A total of 230 preschoolers were included in this study. Specifically, four groups of children were evaluated: ASD individuals suffering from GI symptoms (ASD/GI+), ASD subjects without GI symptoms (ASD/GI-), TD peers with (TD/GI+) and without (TD/GI-) GI symptoms. Parental report of behavioral problems and GI symptoms were assessed through the Child Behavior Check List 11/2-5.Results: A significant higher percentage of ASD (37.4%) versus TD (14.8%) with GI symptoms was observed. 'Constipated' and 'Not-Eat' were the most frequent GI symptoms both in ASD and in TD groups, but they were evaluated as more severe in ASD patients. ASD/GI+ children had more anxiety problems, somatic complaints, externalizing and total problems than ASD/GI-individuals. TD/GI+ did not show more behavioral problems than TD/GI-.Conclusion: Development of evidence-based guidelines for identification of GI problems in ASD preschoolers is warranted. GI symptomatology should be accurately assessed, especially in ASD children with anxiety and/or externalizing behavioral problems. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.