Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes.
Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes.
复制标题
耐红霉素淋病奈瑟菌和口腔共生奈瑟菌。
DOI：
10.1128/aac.43.6.1367
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发表时间：
1999
影响因子：
4.9
通讯作者：
Holmes,KK
中科院分区：
文献类型：
--
作者：
Roberts,MC;Chung,WO;Roe,D;Xia,M;Marquez,C;Borthagaray,G;Whittington,WL;Holmes,KK
2株来自西雅图的淋球菌和2株来自乌拉圭的淋球菌对红霉素耐药(MIC，4~16μg/ml)，而对阿奇霉素(MIC，1~4μg/ml)的敏感性降低，这是由于存在自移动性rRNA甲基酶基因(S)ermForermBandermF。两个西雅图分离株和一个来自乌拉圭的分离株是多重耐药的，携带含有25.2MDatetM的质粒(西雅图)或β-内酰胺酶质粒(乌拉圭)。共分离出16株奈瑟氏菌(10株过黄奈瑟氏菌-N。Sicca，2N.Flava和4N.红霉素最低抑菌浓度为4~16μg/ml的粘膜)携带一个或多个已知的rRNA甲基酶基因，包括ermB、ermC和/或ermF。这些菌株中的许多也是多重耐药的，并携带MetM基因。这是首次为奈瑟氏奈瑟菌属描述携带抗生素耐药基因的完整转座子或完全接合转座子。
TwoNeisseria gonorrhoeaeisolates from Seattle and two isolates from Uruguay were resistant to erythromycin (MIC, 4 to 16 μg/ml) and had reduced susceptibility to azithromycin (MIC, 1 to 4 μg/ml) due to the presence of the self-mobile rRNA methylase gene(s)ermForermBandermF. The two Seattle isolates and one isolate from Uruguay were multiresistant, carrying either the 25.2-MDatetM-containing plasmid (Seattle) or a β-lactamase plasmid (Uruguay). Sixteen commensalNeisseriaisolates (10Neisseria perflava-N. sicca, 2N. flava, and 4N. mucosa) for which erythromycin MICs were 4 to 16 μg/ml were shown to carry one or more known rRNA methylase genes, includingermB,ermC, and/orermF. Many of these isolates also were multiresistant and carried thetetMgene. This is the first time that a complete transposon or a complete conjugative transposon carrying an antibiotic resistance gene has been described for the genusNeisseria.