A FOSTERING STUDY OF THE EFFECTS OF PRENATAL COCAINE EXPOSURE .1. MATERNAL BEHAVIORS
A FOSTERING STUDY OF THE EFFECTS OF PRENATAL COCAINE EXPOSURE .1. MATERNAL BEHAVIORS
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DOI：
10.1016/0892-0362(92)90052-c
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发表时间：
1992-11-01
影响因子：
2.9
通讯作者：
SPEAR, LP
中科院分区：
文献类型：
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作者：
HEYSER, CJ;MOLINA, VA;SPEAR, LP
考察了教养条件和产前可卡因暴露对母亲行为的影响。从妊娠8-20天开始，每天给SpragueDawley母鼠注射40 mg/kg/3cc可卡因盐酸盐(C40)或生理盐水(LC)。母体行为在饲养它们的生物幼崽(LC/LC；C40/C40)、饲养未经处理的幼崽(LC/FOS；C40/FOS)和养育经过处理的幼崽(FOS/LC；FOS/C40)的处理母体中进行了评估。在出生后第4天(P4)的光明和黑暗周期中，对所有母鼠的家笼行为(进食、饮水和与幼崽在一起的时间)进行2小时的监测，在P5-P9的光暗周期中监测幼崽的取回，以及在P10的母体攻击(第一次攻击的潜伏期、攻击次数、拳击、别针、入侵者顺从和静止的时间)。在巢行为和取回幼崽的测试中，六组之间没有观察到差异。与所有其他组相比，饲养它们的生物幼崽(LC/LC和C40/C40)的母鼠发起第一次攻击的速度要快得多。这种增加的攻击性在C40/C40水坝的整个测试过程中一直保持着，这些水坝进行的入侵者攻击比所有其他组都要多得多，入侵者以顺从的姿势(仰卧)花费的时间明显更多。相比之下，LC/LC大坝在测试期间没有表现出更多的攻击次数，显然是对入侵者冰冻增加的反应，减少了攻击行为。综上所述，这些发现表明，以前接触可卡因会导致母体攻击性的改变，当这些母马抚养自己的幼崽时，这一点很明显。
The effect of rearing condition and prenatal exposure to cocaine on maternal behaviors was examined. Sprague-Dawley dams were given SC injections of 40 mg/kg/3cc cocaine HCl (C40) or saline (LC) daily from gestational days 8-20. Maternal behavior was assessed in treated dams rearing their biological pups (LC/LC; C40/C40), treated dams rearing untreated pups (LC/FOS; C40/FOS), and foster dams rearing treated pups (FOS/LC; FOS/C40). All dams were monitored for home cage behavior (time eating, drinking,and with pups) for 2 h during both the light and dark cycle on postnatal day 4 (P4), pup retrieval on P5-P9, and maternal aggression to a female intruder (latency to the first attack, number of attacks, boxing, pins, intruder time spent submissive and motionless) on P10. No differences were observed in nest behavior or in tests of pup retrieval among the six groups. Dams rearing their biological litter (LC/LC and C40/C40) were significantly quicker to initiate the first attack when compared to all other groups. This increased aggression was maintained throughout the test session in the C40/C40 dams who made significantly more intruder attacks than all other groups, with the intruder spending significantly more time in a submissive posture (lying on back). In contrast, LC/LC dams did not exhibit an increased number of attacks during the test, apparently responding to an increased freezing in their intruders with a reduction in aggressive behavior. Taken together these findings suggest that prior cocaine exposure results in alterations in maternal aggression that is evident when these dams rear their own pups.