Startle modulation in children with posttraumatic stress disorder.
Startle modulation in children with posttraumatic stress disorder.
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患有创伤后应激障碍的儿童的惊吓调节。
DOI：
10.1176/ajp.146.7.866
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Pynoos,RS
中科院分区：
文献类型：
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作者：
Ornitz,EM;Pynoos,RS
6名创伤后应激障碍(PTSD)儿童和6名正常对照儿童在创伤后17-21个月记录了对白噪音爆发的惊恐反应为眨眼反射。第七个患有创伤后应激障碍的孩子在一次压力事件后的两年中被研究了四次。为了研究脑干机制对惊厥反应的抑制和易化调节作用，采用非惊厥声预刺激对惊厥反应进行了调制。患有创伤后应激障碍的儿童经历了惊吓反应正常抑制调制的显著丧失，这表明创伤经历导致了长期的脑干功能障碍。
Startle responses to bursts of white noise were recorded as blink reflexes 17-21 months after a traumatic event in six children with posttraumatic stress disorder (PTSD) and in six normal control children. A seventh child with PTSD was studied on four occasions during the 2 years following a stressful event. The startle responses were modulated by nonstartling acoustic prestimulation in order to study the inhibitory and facilitatory modulation of startle reaction by brainstem mechanisms. The children with PTSD experienced a significant loss of the normal inhibitory modulation of startle response, suggesting that the traumatic experience had induced a long-lasting brainstem dysfunction.