Fabrication of polymer monoliths within the confines of non-transparent 3D-printed polymer housings
Fabrication of polymer monoliths within the confines of non-transparent 3D-printed polymer housings
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DOI：
10.1016/j.chroma.2020.461159
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发表时间：
2020-07-19
影响因子：
4.1
通讯作者：
Schoenmakers, Peter
中科院分区：
文献类型：
--
作者：
Abdulhussain, Noor;Nawada, Suhas;Schoenmakers, Peter
在过去的十年中，3D打印已经成为分析化学领域一项有前途的技术。熔融沉积成型（FDM）是一种流行的，低成本和广泛使用的技术。在这项研究中，RPLC分离是通过直接在3D打印通道内原位制造多孔聚合物整料来实现的。热聚合用于在光学不透明柱外壳中制造整体柱，使用两种不同的聚丙烯材料3D打印。丙烯酸酯基和聚苯乙烯基整料都被创建。两种方法用于整料制造，即（i）在标准聚丙烯（PP）中，开发了两步法，其中自由基引发的壁改性步骤2，2 '-偶氮二（2-甲基丙腈）（AIBN）作为引发剂，随后是聚合步骤以生成整料;（ii）对于玻璃增强PP（GPP），在聚合反应之前进行硅烷化步骤或壁改性。使用扫描电子显微镜（SEM）研究了壁附着的成功和整料的形态，并在流动实验中研究了柱的渗透性。在这两种类型的外壳聚苯乙烯-二乙烯基苯（PS-DVB）单片成功地制造了良好的墙壁附着。在玻璃增强聚丙烯（GPP）印刷外壳内，SEM照片显示了径向均匀的整体结构。证明了在3D打印通道中进行液相色谱分离的可行性。(C)2020爱思唯尔B. V.保留所有权利。
In the last decade, 3D-printing has emerged as a promising enabling technology in the field of analytical chemistry. Fused-deposition modelling (FDM) is a popular, low-cost and widely accessible technique. In this study, RPLC separations are achieved by in-situ fabrication of porous polymer monoliths, directly within the 3D-printed channels. Thermal polymerization was employed for the fabrication of monolithic columns in optically non-transparent column housings, 3D-printed using two different polypropylene materials. Both acrylate-based and polystyrene-based monoliths were created. Two approaches were used for monolith fabrication, viz. (i) in standard polypropylene (PP) a two-step process was developed, with a radical initiated wall-modification step 2,2'-azobis(2-methylpropionitrile) (AIBN) as the initiator, followed by a polymerization step to generate the monolith; (ii) for glass-reinforced PP (GPP) a silanization step or wall modification preceded the polymerization reaction. The success of wall attachment and the morphology of the monoliths were studied using scanning electron microscopy (SEM), and the permeability of the columns was studied in flow experiments. In both types of housings polystyrene-divinylbenzene (PS-DVB) monoliths were successfully fabricated with good wall attachment. Within the glass-reinforced polypropylene (GPP) printed housing, SEM pictures showed a radially homogenous monolithic structure. The feasibility of performing liquid-chromatographic separations in 3D-printed channels was demonstrated. (C) 2020 Elsevier B.V. All rights reserved.