Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex
Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex
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DOI：
10.1152/jn.00135.2011
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Lenz, Fred
中科院分区：
文献类型：
--
作者：
Baumgaertner, Ulf;Vogel, Hagen;Lenz, Fred
Baumgartner U，Vogel H，大原S，Treede RD，伦茨F.从初级躯体感觉皮层硬膜下网格记录获得的激光诱发电位的偶极源分析。J Neurophysiol 106：722-730，2011.首次发表于2011年5月18日; doi：10.1152/jn.00135.2011.-由激光刺激的皮肤应用诱发的皮层电位（激光诱发电位，LEP）通常包括初级躯体感觉皮层（S1）中的电位，其可以位于包括布罗德曼区3A、3B、1和2的S1的分区内。LEP发生器的精确位置可以阐明疼痛刺激对人类S1的激活模式。我们现在测试的假设，即发生器的LEP位于人类布罗德曼区1或3A内的S1。局部场电位（LFP）源分析的LEP获得从硬膜下网格在感觉运动皮层在两个病人接受癫痫手术。将LEP偶极子的关系与由正中神经刺激（SEP）诱发并记录在区域3B中的躯体感觉电位的偶极子进行比较（参见Baumgartner U，Vogel H，大原S，Treede RD，伦茨FA. J Neurophysiol 104：3029-3041，2010）。两名患者均在S1出现早期径向偶极子。LEP偶极子位于SEP偶极子的内侧、前部和深部，这表明3A区存在伤害性偶极子。1例患者有一个后切向偶极子，阳性后部，这与3B区SEP偶极子的方向相反。模式之间的方向的逆转是一致的皮质表面的负方向导致的丘脑皮质神经元，从脊髓丘脑束接收输入的表面终止。因此，目前的结果表明，LEP可能会导致一个径向偶极子一致的发电机在区域3A和一个假定的后来切向发电机在区域3B。
Baumgartner U, Vogel H, Ohara S, Treede RD, Lenz F. Dipole source analyses of laser evoked potentials obtained from subdural grid recordings from primary somatic sensory cortex. J Neurophysiol 106: 722-730, 2011. First published May 18, 2011; doi:10.1152/jn.00135.2011.-The cortical potentials evoked by cutaneous application of a laser stimulus (laser evoked potentials, LEP) often include potentials in the primary somatic sensory cortex (S1), which may be located within the subdivisions of S1 including Brodmann areas 3A, 3B, 1, and 2. The precise location of the LEP generator may clarify the pattern of activation of human S1 by painful stimuli. We now test the hypothesis that the generators of the LEP are located in human Brodmann area 1 or 3A within S1. Local field potential (LFP) source analysis of the LEP was obtained from subdural grids over sensorimotor cortex in two patients undergoing epilepsy surgery. The relationship of LEP dipoles was compared with dipoles for somatic sensory potentials evoked by median nerve stimulation (SEP) and recorded in area 3B (see Baumgartner U, Vogel H, Ohara S, Treede RD, Lenz FA. J Neurophysiol 104: 3029-3041, 2010). Both patients had an early radial dipole in S1. The LEP dipole was located medial, anterior, and deep to the SEP dipole, which suggests a nociceptive dipole in area 3A. One patient had a later tangential dipole with positivity posterior, which is opposite to the orientation of the SEP dipole in area 3B. The reversal of orientations between modalities is consistent with the cortical surface negative orientation resulting from superficial termination of thalamocortical neurons that receive inputs from the spinothalamic tract. Therefore, the present results suggest that the LEP may result in a radial dipole consistent with a generator in area 3A and a putative later tangential generator in area 3B.