Patterning of pre-thalamic somatosensory pathways
Patterning of pre-thalamic somatosensory pathways
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DOI：
10.1111/j.1460-9568.2012.08059.x
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发表时间：
2012-05-01
影响因子：
3.4
通讯作者：
Jabaudon, Denis
中科院分区：
文献类型：
--
作者：
Pouchelon, Gabrielle;Frangeul, Laura;Jabaudon, Denis
输入的地形图是感觉通路的基本组织原则。在体感系统中，面部的精确地形表征首先在脑干中生成，然后在丘脑和皮质中忠实地复制。尽管我们对连接面部皮肤机械感受器与新皮质神经元的独特多突触通路的了解最近有所扩展，但在发育过程中控制其神经元类型特异性组装的分子机制仍然知之甚少。越来越多的遗传工具能够以细胞分辨率操纵这些发育中的回路，现在为我们理解分子机制开辟了新的视角，通过该分子机制将来自外围的输入转化为模式化的中央通路。
The topographical mapping of input is a fundamental organizing principle of sensory pathways. In the somatosensory system, a precise topographical representation of the face is first generated in the brainstem and then faithfully replicated in the thalamus and cortex. Although our knowledge of the distinct polysynaptic pathways that link cutaneous mechanoreceptors of the face with neocortical neurons has recently expanded, the molecular mechanisms controlling their neuron-type-specific assembly during development remain poorly understood. The increasing availability of genetic tools that enable manipulation of these developing circuits with cellular resolution now opens new perspectives in our understanding of the molecular mechanisms through which input from the periphery is converted into patterned central pathways.