Inhibition of glycogen synthesis in rat hepatocytes by medium Zn2+.
Inhibition of glycogen synthesis in rat hepatocytes by medium Zn2+.
复制标题
培养基 Zn2 对大鼠肝细胞糖原合成的抑制。
DOI：
10.1016/s0006-291x(84)80094-7
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发表时间：
1984
影响因子：
3.1
通讯作者：
Rognstad,R
中科院分区：
文献类型：
--
作者：
Rognstad,R
In hepatocytes from fasted rats, Zn2+in the range from 0 to 500uM has relatively minor effects on gluconeogenesis from most substrates, or on ureagenesis from NH3. In hepatocytes from fed rats, Zn2+does not affect glycogenolysis. In hepatocytes from fasted rats, in which glycogen is being actively synthesized using the substrate combination (Katz et al. (1976) Proc. Natl.Acad.Sci.USA73,3433–3437) of glucose, lactate and glutamine (all 10mM), Zn2+markedly inhibits glycogen synthesis, with total inhibition at 500uM, and a half maximal effect in the range from 50 to 100uM.Dipicolinate (pyridine 2,6-dicarboxylate), a zinc chelator, is about as effective as L-glutamine in activating glycogen synthesis with the substrate combination of dihydroxyacetone, lactate and glucose (all 10mM). This suggests the possible hypothesis that endogenous Zn2+might control the rate of glycogen synthesisinvivo. However, alternate explanations such as metabolite accumulation are also possible, since dipicolinate causes inhibition of gluconeogenesis from L-lactate.
