Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies.
Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies.
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用于经皮冠状动脉介入治疗（PCI）优化策略的三维虚拟手术模型
DOI：
10.1038/srep10945
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发表时间：
2015-06-04
影响因子：
4.6
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Wang H;Liu J;Zheng X;Rong X;Zheng X;Peng H;Silber-Li Z;Li M;Liu L
经皮冠状动脉介入治疗（PCI），特别是冠状动脉支架植入术，已被证明是治疗冠状动脉疾病的有效方法。然而，支架内再狭窄是PCI术后长期无法解决的问题之一。虽然狭窄血管内植入支架恢复正常流量的血流，他们瞬间改变血管表面的壁切应力（WSS）分布。不适当的支架植入位置带来了再狭窄的高可能性，因为它扩大了低WSS区域，随后刺激了血管壁上更多的上皮细胞生长。为了优化支架位置以降低再狭窄的风险，我们成功地建立了一个基于真实的临床冠状动脉的数字化三维模型，并通过计算机模拟分析了最佳的支架植入策略。通过微加工和3D打印技术，数字模型也被转换成具有3D微通道的体外微流体模型。同时，医生将真实的支架放置在它们内部;即，他们进行“虚拟手术”。流体力学实验结果表明，微流控模型与模拟结果吻合较好。因此，我们的研究不仅证明了半交叉支架植入策略可以最大限度地降低再狭窄风险，而且还表明3D打印结合临床图像重建是未来心血管疾病研究的一种有前途的方法。
Percutaneous coronary intervention (PCI), especially coronary stent implantation, has been shown to be an effective treatment for coronary artery disease. However, in-stent restenosis is one of the longstanding unsolvable problems following PCI. Although stents implanted inside narrowed vessels recover normal flux of blood flows, they instantaneously change the wall shear stress (WSS) distribution on the vessel surface. Improper stent implantation positions bring high possibilities of restenosis as it enlarges the low WSS regions and subsequently stimulates more epithelial cell outgrowth on vessel walls. To optimize the stent position for lowering the risk of restenosis, we successfully established a digital three-dimensional (3-D) model based on a real clinical coronary artery and analysed the optimal stenting strategies by computational simulation. Via microfabrication and 3-D printing technology, the digital model was also converted into in vitro microfluidic models with 3-D micro channels. Simultaneously, physicians placed real stents inside them; i.e., they performed “virtual surgeries”. The hydrodynamic experimental results showed that the microfluidic models highly inosculated the simulations. Therefore, our study not only demonstrated that the half-cross stenting strategy could maximally reduce restenosis risks but also indicated that 3-D printing combined with clinical image reconstruction is a promising method for future angiocardiopathy research.
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通过三维（3D）定量冠状动脉造影对分叉的最佳视角和分叉角度的分叉评估。
影响因子：
2.1
作者：
Tu, Shengxian;Jing, Jing;Holm, Niels R.;Onsea, Kevin;Zhang, Tao;Adriaenssens, Tom;Dubois, Christophe;Desmet, Walter;Thuesen, Leif;Chen, Yundai;Reiber, Johan H. C.
通讯作者：
Reiber, Johan H. C.
DOI：
10.1016/j.ejmp.2013.02.001
发表时间：
2013-09-01
影响因子：
3.4
作者：
Chaichana, Thanapong;Sun, Zhonghua;Jewkes, James
通讯作者：
Jewkes, James
影响因子：
2.3
作者：
Naganuma, Toru;Chieffo, Alaide;Colombo, Antonio
通讯作者：
Colombo, Antonio
影响因子：
4.7
作者：
Kanaris, A. G.;Anastasiou, A. D.;Paras, S. V.
通讯作者：
Paras, S. V.
影响因子：
2.4
作者：
van der Giessen, Alina G.;Groen, Harald C.;Gijsen, Frank J. H.
通讯作者：
Gijsen, Frank J. H.