Hydroxyapatite Cranioplasty: I. Experimental Results From a New Quick-Setting Material
Hydroxyapatite Cranioplasty: I. Experimental Results From a New Quick-Setting Material
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羟基磷灰石颅骨成形术：一、新型快凝材料的实验结果
DOI：
10.1097/00001665-200301000-00015
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发表时间：
2003
影响因子：
0.9
通讯作者：
B. Eppley
中科院分区：
文献类型：
--
作者：
B. Eppley
对一种新配方的羟基磷灰石(HA)在动物体内的生物物理特性进行了评价。利用成熟的兔模型，将该材料应用于颅骨缺损区和几何形状的颅骨高填体。植入1年后进行视觉和组织学评估。材料在1年后保持形态稳定，完全保持其嵌体形状，并稳定填充颅骨缺损处。随着嵌体内外表面和嵌体侧面的骨生长，可以观察到显著的骨传导反应。由于研究动物的年龄或材料的致密密度，材料本身没有明显的纤维血管内生或骨替代。这种快速固化的HA配方提供了与其他较长固化HA材料类似的良好的组织反应。
The biophysical characteristics of a new formulation of hydroxyapatite (HA) for craniofacial applications having a rapid set time was evaluated in animals. Using a mature rabbit model, the material was applied in both cranial defects and as a geometrically shaped cranial onlay. Visual and histological assessment was done after 1 year of implantation. The material remained morphologically stable after 1 year, with complete preservation of its onlay shape and stable fill of the cranial defects. A significant osteoconductive response was seen with bone growth across the inner and outer surfaces of the inlays and along the sides of the onlays. No fibrovascular ingrowth or bony replacement of the material itself was evident as a result of the age of the study animals or the compact density of the material. This rapid-setting HA formulation offers similar favorable tissue responses as those of other longer setting HA materials.