On the co-occurrence of startles and hippocampal sharp waves in newborn rats
On the co-occurrence of startles and hippocampal sharp waves in newborn rats
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DOI：
10.1002/hipo.20224
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发表时间：
2006-01-01
期刊：
影响因子：
3.5
通讯作者：
Blumberg, Mark S.
中科院分区：
文献类型：
--
作者：
Karlsson, Karl AE.;Mohns, Ethan J.;Blumberg, Mark S.
海马尖波（SPW）是在婴儿哺乳动物中观察到的最早的神经群体模式之一。同样，惊吓是观察到的最早的行为事件之一。在这里，我们提供的证据表明，这两个事件在出生后不久，在自由移动和头部固定1至4天的大鼠机械连接。肌电图电极和海马内硅深度电极分别用于检测惊吓和SPW的存在。在完整的幼崽中，大部分尖波之前是惊吓（平均潜伏期：161 ms）。然而，当海马结构通过手术与脑干分离时，尖波和惊吓仍然会发生，但现在是独立的。此外，与惊吓或SPW无关，在几个受试者中检测到伽马振荡，就像被动传播到海马体的新皮质“纺锤体”一样。尖波和惊吓的同时出现为突触功效的赫布变化提供了机会，因此，有望有助于神经回路在发育早期的组装。(c)2006 Wiley-Liss，Inc.
Hippocampal sharp waves (SPWs) are among the earliest neural population patterns observed in infant mammals. Similarly, startles are among the earliest behavioral events observed. Here we provide evidence indicating that these two events are linked mechanistically soon after birth in freely moving and head-fixed 1 to 4-day-old rats. EMG electrodes and intrahippocampal silicon depth electrodes were used to detect the presence of startles and SPWs, respectively. in intact pups, the majority of sharp waves were preceded by startles (average latency: 161 ms). When the hippocampal formation was surgically separated from the brainstem, however, sharp waves and startles still occurred, but now independently. In addition, unrelated to startles or SPWs, gamma oscillations were detected in several subjects, as were neocortical "spindles" that propagated passively into the hippocampus. The cooccurrence of sharp waves and startles provides the opportunity for Hebbian changes in synaptic efficacy and, thus, is poised to contribute to the assembly of neural circuits early in development. (c) 2006 Wiley-Liss, Inc.