Effects of fornix transection and cingulate cortical ablation on spatial memory in rhesus monkeys
Effects of fornix transection and cingulate cortical ablation on spatial memory in rhesus monkeys
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DOI：
10.1007/bf00248291
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发表时间：
2004
影响因子：
2
通讯作者：
Elisabeth A. Murray;M. Davidson;D. Gaffan;D. Olton;S. Suomi
中科院分区：
文献类型：
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作者：
Elisabeth A. Murray;M. Davidson;D. Gaffan;D. Olton;S. Suomi
这项研究，以及一项对大鼠的平行研究(Markowska等人)。1988年)，试图将大鼠和猴子的海马体系统损伤对类似任务的影响联系起来。不仅给猴子分配了一项通常用于老鼠的任务(实验1)，而且在同伴研究中，给老鼠分配了通常用于猴子的任务(实验2)。实验一考察了海马区受损的恒河猴在空间工作记忆任务中的表现。猴子在手术前在T-迷宫中接受延迟不匹配到样本的训练，被分成与他们术前学习分数匹配的小组，然后接受三种治疗之一：1)切断穹隆；2)切除扣带皮质；或3)假手术。与对照组相比，穹隆横断的猴子受到严重和显著的损害，但扣带皮质切除的猴子没有受到明显的损害。结果表明，穹隆横断的猴子在需要运动的空间工作记忆任务中受到严重损害，结合早期的工作，表明穹隆横断对啮齿动物和非人类灵长类动物的影响至少在性质上是相似的(参见Markowska等人。(1988年)。实验2评估了穹隆和扣带回皮质在三个条件任务中的作用，在这些任务中，猴子被提供了不同的空间线索，以表明两个物体中的哪一个得到了奖励。与对照组相比，两个实验组在所有三个任务中都没有受到损害，这表明穹隆横断并不会导致位置学习的普遍损害。
This study, together with a parallel study in rats (Markowska et al. 1988), attempted to relate the effects of hippocampal-system damage on similar tasks in both rats and monkeys. Not only were monkeys given a task (Experiment 1) which was of the sort usually used with rats, but in the companion study rats were given tasks (Experiment 2) like those usually used with monkeys. Experiment 1 examined the performance of rhesus monkeys with hippocampal-system damage on a spatial working memory task. Monkeys were trained preoperatively on delayed nonmatching-to-sample in a T-maze, placed into groups matched for their preoperative learning scores, and then received one of three treatments: 1) transection of the fornix; 2) ablation of the cingulate cortex; or 3) a sham operation. Monkeys with fornix transection were severely and significantly impaired, but monkeys with cingulate cortical ablations were not significantly impaired, relative to the controls. The results demonstrate that monkeys with fornix transection are severely impaired on a spatial working memory task requiring locomotion and, taken together with earlier work, suggest that the effect of fornix transection in both rodents and nonhuman primates is at least qualitatively similar (see Markowska et al. 1988). Experiment 2 assessed the role of the fornix and cingulate cortex in three conditional tasks in which the monkeys were provided with various spatial cues to indicate which one of two objects was rewarded. Both experimental groups were unimpaired, relative to the control group, on all three tasks, indicating that fornix transection does not produce a general impairment in place learning.