Crossed unilateral lesions of temporal lobe structures and cholinergic cell bodies impair visual conditional and object discrimination learning in monkeys
Crossed unilateral lesions of temporal lobe structures and cholinergic cell bodies impair visual conditional and object discrimination learning in monkeys
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DOI：
10.1046/j.0953-816x.2001.01888.x
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发表时间：
2002-02-01
影响因子：
3.4
通讯作者：
Ridley, RM
中科院分区：
文献类型：
--
作者：
Barefoot, HC;Baker, HF;Ridley, RM
猴子的CA 1/下托区域在右半球和免疫毒性病变的胆碱能细胞的斜角带在左半球的兴奋性病变受损的视觉条件任务。在这个任务中，正确选择两个对象之一取决于两个对象的两个背景场中的哪一个，而不管对象的空间位置如何，它们在简单的对象或形状辨别任务中没有受损。损伤的模式与双侧CA 1/下托兴奋性毒性损伤后观察到的相同，这意味着斜角带损伤使同侧CA 1/下托丧失功能。它还认为，CA 1/下托，持续的胆碱能输入，是必要的某些形式的非空间条件性学习。除了颞下（IT）皮层消融左半球没有影响简单的视觉辨别学习，虽然所有的猴子，然后未能学习一个新的视觉条件任务。这表明，完整的IT皮层在只有一个半球是足以维持简单的视觉辨别学习，但意味着胆碱能输入和下颞叶皮层输入海马都有助于视觉条件性学习。随后添加的免疫毒性病变的基底核的Meynert在右半球导致额外的障碍，难以辨别形状。这表明，是胆碱能投射到颞下皮层，而不是其他皮层，这有助于视觉辨别学习和记忆。
Monkeys with excitotoxic lesions of the CA1/subiculum region in the right hemisphere and with immunotoxic lesions of the cholinergic cells of the diagonal band in the left hemisphere were impaired on a visual conditional task. In this task, correct choice of one of two objects depends on which of two background fields both objects are presented against, irrespective of the spatial positions of the objects, They were not impaired on simple object or shape discrimination tasks. The pattern of impairments is the same as that seen after bilateral excitotoxic lesions of CA1/subiculum, implying that the diagonal band lesion disables the ipsilateral CA1/subiculum. It also argues that CA1/subiculum, sustained by its cholinergic input, is necessary for some forms of nonspatial conditional learning. Addition of an inferotemporal (IT) cortical ablation to the left hemisphere did not affect simple visual discrimination learning, although all the monkeys then failed to learn a new visual conditional task. This demonstrates that intact IT cortex in only one hemisphere is sufficient to sustain simple visual discrimination learning but implies that the cholinergic input and the inferotemporal cortical input to the hippocampus both contribute to visual conditional learning. The subsequent addition of an immunotoxic lesion of the basal nucleus of Meynert in the right hemisphere resulted in an additional impairment on a difficult shape discrimination. This argues that it is the cholinergic projection to the inferotemporal cortex, rather than to the rest of the cortex, which contributes to visual discrimination learning and memory.