STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : II. PROTECTIVE EFFECT OF THE BACTERICIDAL AGENT AGAINST EXPERIMENTAL PNEUMOCOCCUS INFECTIONS IN MICE.
STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : II. PROTECTIVE EFFECT OF THE BACTERICIDAL AGENT AGAINST EXPERIMENTAL PNEUMOCOCCUS INFECTIONS IN MICE.
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DOI：
10.1084/jem.70.1.11
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发表时间：
1939-06-30
期刊：
影响因子：
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通讯作者：
Dubos RJ
中科院分区：
文献类型：
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作者：
Dubos RJ
在本系列的第一篇文章中，描述了从特定土壤杆菌菌株的自溶物中获得的无细胞提取物，该提取物选择性抑制迄今为止测试的所有革兰氏阳性微生物的生长，并在体外对它们发挥杀菌作用。本研究表明，相同的药物可以保护小白鼠免受大量有毒力肺炎球菌的感染。当给小鼠注射感染生物体数小时后，它也能发挥疗效。对于所有强毒力肺炎球菌，无论类型特异性如何，所提供的保护程度和杀菌剂的最小有效剂量大致相同。该杀菌剂对剧毒弗里迪安德杆菌（B 型）感染完全无效。这与该试剂在体外不影响革兰氏阴性杆菌的事实相一致。杀菌剂对实验性肺炎球菌感染所发挥的保护作用取决于决定其体外杀菌效果的相同机制。
In the first paper of this series, a description was given of a cell-free extract, obtained from autolysates of a particular strain of a soil bacillus, which selectively inhibits the growth of all the Gram-positive microorganisms so far tested, and exerts on them a bactericidal effect in vitro. In the present study it is shown that the same agent protects white mice against infection with large numbers of virulent pneumococci. It also exerts a curative effect when administered to mice several hours after injection of the infecting organisms. The degree of protection afforded, and the minimal effective dose of bactericidal agent, are approximately the same for all virulent pneumococci, irrespective of type specificity. The bactericidal agent is entirely ineffective against infection with virulent Friediänder bacilli (type B). This agrees with the fact that the agent does not affect Gram-negative bacilli in vitro. The protective action exerted by the bactericidal agent against experimental pneumococcus infection depends upon the same mechanism which determines its bactericidal effect in vitro.