Changes in bone mineral density, lean body mass and fat content as measured by dual energy X-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy
Changes in bone mineral density, lean body mass and fat content as measured by dual energy X-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy
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DOI：
10.1016/s0022-5347(05)64985-3
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发表时间：
2002-06-01
影响因子：
6.6
通讯作者：
Angeli, A
中科院分区：
文献类型：
--
作者：
Berruti, A;Dogliotti, L;Angeli, A
目的：我们描述了雄激素剥夺治疗对老年男性身体成分的影响。材料与方法：采用双能x线吸收仪测定35例未发生骨转移的前列腺癌患者接受促黄体生成素释放激素类似物治疗12个月后骨密度、骨矿物质含量、脂肪体质量和瘦体质量的变化。结果：在基线条件下，46%的病例为腰椎骨质减少，14%为腰椎骨质疏松，40%为髋部骨质减少，4%为髋部骨质疏松。雄激素剥夺显著降低腰椎骨密度（平均毫克/厘米）。(2)基线、6个月和12个月时[SD]分别为1.00[0.194]、0.986[0.172]和0.977 [0.182]
Purpose: We characterize the consequences of androgen deprivation therapy on body composition in elderly men.Materials and Methods: Using a dual energy x-ray absorptiometry instrument, we determined the changes in bone mineral density, bone mineral content, fat body mass and lean body mass in 35 patients with prostate cancer without bone metastases who received luteinizing hormone releasing hormone analogue for 12 months.Results: At baseline conditions 46% of cases were classified as osteopenic and 14% as osteoporotic at the lumbar spine and 40% were osteopenic and 4% osteoporotic at the hip. Androgen deprivation significantly decreased bone mineral density either at the lumbar spine (mean gm./cm.(2) [SD] 1.00 [0.194], 0.986 [0.172] and 0.977 [0.182] at baseline, and 6 and 12 months, respectively, p