Cognitive deficits in docosahexaenoic acid-deficient rats
Cognitive deficits in docosahexaenoic acid-deficient rats
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DOI：
10.1037//0735-7044.116.6.1022
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发表时间：
2002-12-01
影响因子：
1.9
通讯作者：
Salem, N
中科院分区：
文献类型：
--
作者：
Catalan, J;Moriguchi, T;Salem, N
本研究研究了脑二十二碳六烯酸（DHA）缺乏对第二代（172）成年雄性大鼠简单和复杂嗅觉学习记忆的影响。在n-3充足或缺乏的饮食中饲养的大鼠进行了嗅觉学习和嗅觉记忆任务的获得测试，以及获得水奖励的动机。尽管大脑DHA减少了76%，n-3缺乏的大鼠能够获得最简单的两种气味辨别任务，但在获得20个问题的嗅觉学习集方面存在缺陷。这种缺陷不能归因于感觉能力的变化，相反，它似乎代表了更高层次——学习能力的缺陷。
This study investigated the influence of brain docosahexaenoic acid (DHA) deficiency on simple and complex olfactory-based learning and memory in 2nd generation (172) adult male rats. Rats raised and maintained on either an n-3-adequate or an n-3-deficient diet were tested for acquisition of an olfactory learning set and an olfactory memory task, and for motivation to obtain a water reward. Despite a 76% decrease in brain DHA, n-3-deficient rats were able to acquire most simple 2-odor discrimination tasks but were deficient in the acquisition of a 20-problem olfactory learning set. This deficit could not be attributed to changes in sensory capacity but, instead, appeared to represent a deficit in higher order,learning.