PRIMARY PULMONARY ARTERY SARCOMA. Report of Two Autopsy Cases Studied by Immunohistochemistry and Electron Microscopy, and Review of 110 Cases Reported in the Literature
PRIMARY PULMONARY ARTERY SARCOMA. Report of Two Autopsy Cases Studied by Immunohistochemistry and Electron Microscopy, and Review of 110 Cases Reported in the Literature
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DOI：
10.1111/j.1440-1827.1988.tb02360.x
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发表时间：
1988-07
影响因子：
2.2
通讯作者：
A. Nonomura;H. Kurumaya;N. Kono;Y. Nakanuma;G. Ohta;Shintaroh Terahata;F. Matsubara;T. Matsuda
中科院分区：
文献类型：
--
作者：
A. Nonomura;H. Kurumaya;N. Kono;Y. Nakanuma;G. Ohta;Shintaroh Terahata;F. Matsubara;T. Matsuda
报告了两例原发性肺动脉肉瘤。第1例患者为61岁男性，有咳嗽、劳力性呼吸困难2年病史，入院2个月后因顽固性心力衰竭死亡，且未明确心力衰竭病因相关诊断。尸检发现肺干内有无蒂肿瘤，肺部有孤立性转移病灶。进行了组织学、免疫组织细胞化学和电子显微镜研究，并诊断为恶性间叶瘤。第二例患者是一名 32 岁男性，主诉劳力性呼吸困难和背痛。放射学研究表明纵隔肿瘤累及肺动脉。开胸探查发现纵隔肿块源自左肺动脉。他在出现最初症状 26 个月后死于呼吸衰竭。对手术和尸检材料的组织学、免疫细胞化学和电子显微镜研究揭示了恶性纤维组织细胞瘤。我们回顾了一百十个先前报道的这种肿瘤的病例，并讨论了其临床病理学和形态学特征以及可能的组织发生。 ACTA PATHOL JPN 38：883∼896，1988。
Two cases of primary pulmonary artery sarcoma are reported. The patient in the first case was a 61‐year‐old male with a two‐year history of cough and exertional dyspnea, who died of intractable cardiac failure two months after admission without establishment of a diagnosis related to the etiology of cardiac failure. Autopsy revealed a sessile tumor within the pulmonary trunk and a solitary metastatic lesion in the lung. Histologic, immunohistocyto‐chemical and electron microscopic studies were performed and a diagnosis of malignant mesenchymoma was made. The patient in the second case was a 32‐year‐old male complaining of exertional dyspnea and back pain. Radiologic studies indicated a mediastinal tumor involving the pulmonary artery. Exploratory thoracotomy revealed that the mediastinal mass arose from the left pulmonary artery. He died of respiratory failure 26 months after onset of his initial symptoms. Histologic, immunocytochemical and electron microscopic studies of both surgical and autopsy materials revealed a malignant fibrous histiocytoma. One hundred ten previously reported cases of this tumor are reviewed, and its clinicopathologic and morphologic features and probable histogenesis are discussed. ACTA PATHOL JPN 38: 883∼896, 1988.