Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
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DOI：
10.1210/jc.2006-0328
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发表时间：
2006-08-01
影响因子：
5.8
通讯作者：
Premachandra, Bhartur N.
中科院分区：
文献类型：
--
作者：
Fontana, Luigi;Klein, Samuel;Premachandra, Bhartur N.
背景：热量限制（CR）延缓哺乳动物衰老。据推测，T-3激素的减少可以通过节约能量和减少自由基的产生来延长寿命。目的：本研究的目的是评估长期CR与充足蛋白质和微量营养素摄入对健康瘦体重稳定的成年男性和女性甲状腺功能的关系。设计、环境和参与者：在这项研究中，28名男性和女性（平均年龄，52 +/- 12岁）服用CR饮食3-15年（6 +/- 3年），28名年龄和性别匹配的久坐（WD）和28名体脂匹配的运动（EX）受试者服用西方饮食，评估血清甲状腺激素。主要观察指标：血清总T-4和游离T-4、总T-3和游离T-3、逆转T-3和TSH浓度是主要观察指标。结果：CR组能量摄取量（1779 +/- 355 kcal/d）低于WD组（2433 +/- 502 kcal/d）和EX组（2811 +/- 711 kcal/d） （P < 0.001）。CR组血清T-3浓度低于WD和EX组（分别为73.6 +/- 22和91.0 +/- 13和94.3 +/- 17 ng/dl）
Context: Caloric restriction (CR) retards aging in mammals. It has been hypothesized that a reduction in T-3 hormone may increase life span by conserving energy and reducing free-radical production.Objective: The objective of the study was to assess the relationship between long-term CR with adequate protein and micronutrient intake on thyroid function in healthy lean weight-stable adult men and women.Design, Setting, and Participants: In this study, serum thyroid hormones were evaluated in 28 men and women (mean age, 52 +/- 12 yr) consuming a CR diet for 3-15 yr (6 +/- 3 yr), 28 age- and sex-matched sedentary (WD), and 28 body fat-matched exercising (EX) subjects who were eating Western diets.Main Outcome Measures: Serum total and free T-4, total and free T-3, reverse T-3, and TSH concentrations were the main outcome measures.Results: Energy intake was lower in the CR group (1779 +/- 355 kcal/d) than the WD (2433 +/- 502 kcal/d) and EX (2811 +/- 711 kcal/d) groups (P < 0.001). Serum T-3 concentration was lower in the CR group than the WD and EX groups (73.6 +/- 22 vs. 91.0 +/- 13 vs. 94.3 +/- 17 ng/dl, respectively) (P