Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis
Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis
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早期阶段 [^(11)C]BF-227 PET 分析及其在 3D-SSP 分析的晚期图像解剖标准化中的应用
DOI：
10.1007/s11604-013-0276-7
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发表时间：
2014
期刊：
影响因子：
2.1
通讯作者：
Kudo Y
中科院分区：
文献类型：
--
作者：
Kaneta T;Okamura N;Arai A;Takanami K;Furukawa K;Tashiro M;Furumoto S;Iwata R;Takahashi S;Arai H;Y anai K;Kudo Y
目的探讨早期[11 C]BF-227正电子发射断层扫描（PET）的有效性，以（1）通过提供灌注样信息赋予额外的诊断价值，（2）使用三维立体定向表面投影（3D-SSP）方法获得适当的解剖标准化（AS）。和17名正常认知（NC）受试者。分别在注射后0-10分钟和40-60分钟获得早期和晚期BF-227 PET图像。采用两种方法进行晚期BF-227图像的AS：（1）方法A，使用同一受试者的8 F-氟脱氧葡萄糖（FDG）图像进行晚期BF-227图像的AS;（2）方法B，使用早期BF-227图像进行晚期BF-227图像的AS。AD和MCI组FDG PET和早期BF-227 PET的3D-SSP分析的Z评分图显示典型的AD样模式。区域分析显示，早期阶段BF-227 PET显示AD和NC，MCI和NC之间的显着差异。结论早期阶段BF-227 PET图像显示AD和MCI组显着异常结果。使用早期BF-227图像的晚期BF-227图像的AS是成功的，并且能够进行适当的3D-SSP分析。
PurposeTo examine the usefulness of the early phase [11C]BF-227 positron emission tomography (PET) for (1) conferring additional diagnostic value by providing perfusion-like information and (2) obtaining the appropriate anatomical standardization (AS) using three-dimensional stereotactic surface projection (3D-SSP) method.MethodsThis study included 20 mild cognitive impairment (MCI), 19 Alzheimer’s disease (AD), and 17 normal cognitive (NC) subjects. Early- and late-phase BF-227 PET images were obtained 0–10 and 40–60 min after the injection, respectively. AS for late-phase BF-227 images were performed by 2 methods: (1) method A, for AS of late-phase BF-227 images using8F-fluorodeoxyglucose (FDG) images of the same subject and (2) method B, for AS of late-phase BF-227 images using early phase BF-227 images.ResultsMethod B was successfully used for AS in all cases. The Z score maps of 3D-SSP analyses of FDG PET and early phase BF-227 PET for AD and MCI groups showed a typical AD-like pattern. Regional analyses revealed that the early phase BF-227 PET showed significant differences between AD and NC, and MCI and NC.ConclusionThe early phase BF-227 PET images showed significant abnormal findings for the AD and MCI groups. AS of late-phase BF-227 images using early phase BF-227 images were successful, and enabled appropriate 3D-SSP analyses.