Protection of normal cells and tissues during radio- and chemosensitization of tumors by 2-deoxy-D-glucose
Protection of normal cells and tissues during radio- and chemosensitization of tumors by 2-deoxy-D-glucose
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DOI：
10.4103/0973-1482.55138
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发表时间：
2009-09-01
影响因子：
1.3
通讯作者：
Dwarakanath, B. S.
中科院分区：
文献类型：
--
作者：
Farooque, Abdullah;Afrin, Farhat;Dwarakanath, B. S.
正常组织毒性是癌症治疗的主要限制因素之一。对正常组织和关键器官的损伤限制了更高治疗剂量的使用，从而损害了疗效。葡萄糖类似物2-脱氧-D-葡萄糖（2-DG）是一种糖酵解ATP产生的抑制剂，已显示在体外和体内条件下在许多癌细胞中增强辐射和化疗药物诱导的损伤，同时保留或保护正常细胞。本文综述了目前对2-DG保护正常细胞和组织免受放射和化疗药物诱导的损伤的认识，使这种葡萄糖类似物成为癌症治疗的理想辅助剂。
Normal tissue toxicity is one of the major limiting factors in cancer therapy. Damage to normal tissues and critical organs restricts the use of higher therapeutic doses thereby compromising the efficacy. The glucose analog 2-deoxy-D-glucose (2-DG), an inhibitor of glycolytic ATP production has been shown to enhance radiation- and chemotherapeutic drug-induced damage in a number of cancer cells under in vitro and in vivo conditions while sparing or protecting normal cells. This review summarizes current understanding on the protection of normal cells and tissues against radiation- and chemotherapeutic drug-induced damage by 2-DG that makes this glucose analog an ideal adjuvant in cancer therapy.