Bowman-Birk inhibitor concentrate reduces colon inflammation in mice with dextran sulfate sodium-induced ulcerative colitis
Bowman-Birk inhibitor concentrate reduces colon inflammation in mice with dextran sulfate sodium-induced ulcerative colitis
复制标题
DOI：
10.1023/a:1026616832119
复制
发表时间：
1999-05-01
影响因子：
3.1
通讯作者：
Kennedy, AR
中科院分区：
文献类型：
--
作者：
Ware, JH;Wan, XS;Kennedy, AR
Bowman-Birk抑制剂浓缩物（BBIC）是富含Bowman-Birk抑制剂的大豆提取物，一种蛋白质蛋白酶抑制剂。Bowman-Birk抑制剂可以抑制炎症介导细胞释放的蛋白酶，抑制免疫细胞分泌超氧阴离子自由基。本研究探讨Bowman-Birk抑制剂浓缩物对溃疡性结肠炎（一种炎症性肠病）模型结肠炎症的抑制能力。与标准饮食的小鼠相比，在葡聚糖硫酸钠治疗期间和之后给予食物中添加0.5% BBIC的小鼠，4项组织病理学炎症评分中的3项受到抑制（P < 0.01），总组织病理学评分（P < 0.01），死亡率降低15% (P < 0.01)，死亡率延迟发作。我们的结论是，饮食中的Bowman-Birk抑制剂浓缩物可以对葡聚糖硫酸钠治疗的小鼠产生有益的影响，并且可能对治疗人类炎症性肠病，特别是溃疡性结肠炎有用。
Bowman-Birk inhibitor concentrate (BBIC) is a soybean extract enriched in the Bowman-Birk inhibitor, a protein protease inhibitor. The Bowman-Birk inhibitor can inhibit proteases released from inflammation mediating cells and suppress superoxide anion radical secretion from immunocytes. This study investigates the ability of Bowman-Birk inhibitor concentrate to inhibit colon inflammation in the dextran sulfate sodium model of ulcerative colitis, an inflammatory bowel disease. When compared to mice on a standard diet, mice given food supplemented with 0.5% BBIC during and after dextran sulfate sodium treatment showed suppression of three of four scored histopathological inflammation criteria (P < 0.01), total histopathological score (P < 0.01), a 15% lower mortality rate (P < 0.01), and a delayed onset of mortality. We conclude that dietary Bowman-Birk inhibitor concentrate can beneficially affect dextran sulfate sodium-treated mice and may be useful in the treatment of human inflammatory bowel diseases, particularly ulcerative colitis.