The epileptic seizures induced by BmK I, a modulator of sodium channels
The epileptic seizures induced by BmK I, a modulator of sodium channels
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DOI：
10.1016/j.expneurol.2005.09.006
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发表时间：
2006-01-01
影响因子：
5.3
通讯作者：
Ji, YH
中科院分区：
文献类型：
--
作者：
Bai, ZT;Zhao, R;Ji, YH
在本研究中，研究了海马内给予从中国蝎毒中纯化的钠通道调节剂BmK 1诱导的大鼠癫痫发作的易感性（]。结果表明，BmK I可诱发大鼠强烈的癫痫行为和海马放电，并呈剂量依赖性。海马c-Fos表达呈双峰型，在BmK 1诱导的特定时空模式中呈双峰型。全细胞膜片钳记录显示，BmK 1可明显延长培养大鼠海马神经元钠电流的失活时间，冲洗后可部分恢复。结果提示，大鼠海马是BmK 1致痫作用的敏感靶区，BmK 1诱导大鼠癫痫发作可能与其调节分布于海马神经元的电压门控钠通道失活有关。(c)2005年爱思唯尔公司All rights reserved.
In the present study, the Susceptibility to rat epileptic seizures induced by the intrahippocampal administration of BmK 1, a modulator of sodium channels purified from the venom of Chinese scorpion, has been investigate(]. The results showed that the strong epileptic behaviors and discharges in the hippocampus were evoked by BmK I dose-dependently. The hippocampal c-Fos expression displayed two peak waves in a specific spatio-temporal pattern elicited by BmK 1. The whole cell patch clamp recordings showed that the inactivation of sodium currents in rat cultured hippocampal neurons was prolonged significantly by BmK 1, and restored partially after washing. These results indicated that the rat hippocampus is a susceptible target for the proconvulsant effects of BmK 1, and the induction of epileptic seizures may be ascribed to the modulation of BmK I on the inactivation of voltage-gated sodium Channels distributing in the rat hippocampal neurons. (c) 2005 Elsevier Inc. All rights reserved.