Circadian Rhythms, Sleep, and Disorders of Aging.
Circadian Rhythms, Sleep, and Disorders of Aging.
复制标题
DOI：
10.1016/j.tem.2016.02.003
复制
发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Sehgal A
中科院分区：
文献类型：
--
作者：
Mattis J;Sehgal A
睡眠：众所周知，患有神经退行性疾病的人的清醒周期会被打乱。这些发现现在得到了其中一些疾病的动物模型数据的支持，这引发了睡眠/昼夜节律紊乱是否会导致神经功能丧失的问题。由于昼夜节律和睡眠巩固也会随着正常衰老而中断，这些变化可能是导致衰老成为阿尔茨海默病等疾病的风险因素的部分原因。昼夜节律/睡眠失调和神经退行性变之间联系的潜在机制尚不清楚，但最近的几项研究提供了有趣的可能性。虽然机制分析正在进行中，但值得考虑将昼夜节律/睡眠中断的治疗作为缓解神经退行性疾病症状的一种手段。
Sleep:wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease. Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is underway, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.