The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins
The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins
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DOI：
10.1023/a:1021618719735
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发表时间：
1999-11-01
影响因子：
2.6
通讯作者：
Boomsma, DI
中科院分区：
文献类型：
--
作者：
Koopmans, JR;Slutske, WS;Boomsma, DI
对青少年物质使用各方面的遗传和环境决定因素知之甚少。本研究探讨了青少年开始吸烟的遗传是否独立于吸烟数量的遗传。另一种多因素阈值模型应用于1676荷兰青少年双胞胎对烟草使用的数据。被认为是三个模型（一）单一的责任维度模型，（二）独立的责任维度模型，（三）组合模型（CM），结果表明，有没有一个潜在的连续的吸烟的责任。CM是最佳拟合模型。这一模式假定，有单独的开始和数量方面，但考虑到可能有一些人对消费水平的责任很低，以至于他们不使用烟草。有没有男性和女性之间的遗传和环境的影响程度上的吸烟开始和吸烟量的个体差异的差异。吸烟开始受遗传因素（39%）和共同环境影响（54%）的影响。一旦开始吸烟，遗传因素在很大程度上（86%）决定了吸烟量。
Not much is known about the genetic and environmental determinants of various aspects of substance use in adolescents. This study examined whether the inheritance of initiation of tobacco use in adolescents is independent of the inheritance of the number of cigarettes smoked. Alternative multifactorial threshold models were applied to data on tobacco use in 1676 Dutch adolescent twin pairs. The three models that were considered are (i) the single liability dimension model, (ii) the independent liability dimension model, and (iii) the combined model (CM), The results showed that there is not one underlying continuum of liability to smoking. The CM was the best-fitting model. This model postulates that there are separate initiation and quantity dimensions but allows for the possibility that there are some individuals who are so low on the liability to level of consumption that they are not using tobacco. There were no differences between males and females in the magnitude of the genetic and environmental influences on individual differences in smoking initiation and quantity smoked. Smoking initiation was influenced by genetic factors (39%) and shared environmental influences (54%), Once smoking is initiated genetic factors determine to a large extent (86%) the quantity that is smoked.