Asymptomatic infection with highly pathogenic avian influenza H5N1 in wild birds: how sound is the evidence?
Asymptomatic infection with highly pathogenic avian influenza H5N1 in wild birds: how sound is the evidence?
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DOI：
10.1186/1743-422x-3-96
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发表时间：
2006-11-17
期刊：
影响因子：
4.8
通讯作者：
Yasue, Mai
中科院分区：
文献类型：
--
作者：
Feare, Chris J.;Yasue, Mai
分离出高致病性禽流感病毒H5N1的野生鸟类的广泛死亡表明，该病毒对它们仍然是致命的。然而，一些野生鸟类的无症状携带可能使鸟类在迁徙中传播病毒。因此，确认这种携带对于设计家禽疾病缓解措施非常重要。最近的两篇论文报道了从中国和俄罗斯的少量水鸟中分离出H5N1病毒，并得出结论，野生鸟类可以通过迁徙远距离传播病毒。然而，这两篇论文在提供鸟类学和相关数据方面存在弱点，从而影响了关于野生鸟类在H5N1传播中所起作用的结论。我们描述了这些研究的弱点，并强调需要在适当的情况下改进方法学描述和方法，以及进一步的研究。严格评估野鸟是否能无症状地携带H5N1对于评估候鸟在长途迁徙中传播的风险至关重要。
Widespread deaths of wild birds from which highly pathogenic avian influenza virus H5N1 has been isolated suggest that the virus continues to be lethal to them. However, asymptomatic carriage by some wild birds could allow birds to spread the virus on migration. Confirmation of such carriage is therefore important for the design of mitigation measures for the disease in poultry. Two recent papers have reported the isolation of H5N1 from a small number of water birds in China and Russia and have concluded that wild birds can spread the viruses over long distances on migration. However, both papers contain weaknesses in the provision of ornithological and associated data that compromise conclusions that can be reached about the role of wild birds in the spread of H5N1. We describe the weaknesses of these studies and highlight the need for improved methodological description and methodology, where appropriate, and further research. A rigorous assessment of whether wild birds can carry H5N1 asymptomatically is critical to evaluating the risks of spread by migratory birds on long-distance migration.