Response inhibition and ADHD traits: correlates and heritability in a community sample.
Response inhibition and ADHD traits: correlates and heritability in a community sample.
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DOI：
10.1007/s10802-012-9693-9
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发表时间：
2013-04
影响因子：
3.6
通讯作者：
Schachar RJ
中科院分区：
文献类型：
--
作者：
Crosbie J;Arnold P;Paterson A;Swanson J;Dupuis A;Li X;Shan J;Goodale T;Tam C;Strug LJ;Schachar RJ
内表型或中间表型在神经精神遗传学中引起极大兴趣，因为它们具有促进基因发现的潜力。我们评估了来自停止任务的反应抑制，潜伏期和变异性措施作为ADHD的内表型，通过测试它们是否与一般人群中的ADHD性状相关，与ADHD性状的遗传和共享遗传风险。参与者是16，099名儿童和青少年，年龄在6至18岁之间，他们参观了当地的科学中心。我们使用ADHD症状和正常行为（SWAN）评定量表的优势和劣势以及停止信号任务（SST）-反应抑制（SSRT），反应潜伏期（GoRT）和反应变异性（GoRTSD）的表现来测量ADHD特征。回归分析用于评估认知测量和ADHD特征的关系，同时控制家庭，年龄，性别，种族，社会经济地位和治疗状况。使用SOLAR对来自3，507个家庭的7，483名兄弟姐妹（包括多个兄弟姐妹）的ADHD和认知特征的遗传力进行了估计。双变量之间的关系对变量进行了检查。ADHD特质得分越高的个体，反应抑制越差，反应潜伏期越慢，变异性越大。年轻的参与者和女孩的表现较差，虽然性别的影响是最小的，在最年轻的参与者明显。抑制，潜伏期，变异性，总ADHD性状，注意力不集中和多动-冲动得分显着遗传。ADHD特征和抑制，但不是潜伏期或变异性是可共遗传的。在对一般人群进行的最大规模的研究中，我们发现反应抑制作为ADHD的内表型的有效性得到了支持。本文的在线版本（doi：10.1007/s10802-012-9693-9）包含补充材料，可供授权用户使用。
Endophenotypes or intermediate phenotypes are of great interest in neuropsychiatric genetics because of their potential for facilitating gene discovery. We evaluated response inhibition, latency and variability measures derived from the stop task as endophenotypes of ADHD by testing whether they were related to ADHD traits in the general population, heritable and shared genetic risk with ADHD traits. Participants were 16,099 children and adolescents, ages 6 to 18 years who visited a local science center. We measured ADHD traits using the Strengths and Weaknesses of ADHD-symptoms and Normal-Behavior (SWAN) rating scale and performance on the stop signal task (SST)—response inhibition (SSRT), response latency (GoRT), and response variability (GoRTSD). Regression analysis was used to assess the relationship of cognitive measures and ADHD traits while controlling for family, age, sex, ethnicity, socioeconomic status and treatment status. Heritability of ADHD and cognitive traits was estimated using SOLAR in 7,483 siblings from 3,507 families that included multiple siblings. Bivariate relationships between pairs of variables were examined. Individuals with greater ADHD trait scores had worse response inhibition, slower response latency, and greater variability. Younger participants and girls had inferior performance although the gender effects were minimal and evident in youngest participants. Inhibition, latency, variability, total ADHD traits, inattention and hyperactivity-impulsivity scores were significantly heritable. ADHD traits and inhibition, but not latency or variability were coheritable. In the largest study in the general population, we found support for the validity of response inhibition as an endophenotype of ADHD. The online version of this article (doi:10.1007/s10802-012-9693-9) contains supplementary material, which is available to authorized users.
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影响因子：
5.3
作者：
Franke B;Neale BM;Faraone SV
通讯作者：
Faraone SV
影响因子：
11
作者：
Kendler, K. S.;Neale, M. C.
通讯作者：
Neale, M. C.
DOI：
10.1016/j.jaac.2010.06.008
发表时间：
2010-09
影响因子：
13.3
作者：
Neale BM;Medland SE;Ripke S;Asherson P;Franke B;Lesch KP;Faraone SV;Nguyen TT;Schäfer H;Holmans P;Daly M;Steinhausen HC;Freitag C;Reif A;Renner TJ;Romanos M;Romanos J;Walitza S;Warnke A;Meyer J;Palmason H;Buitelaar J;Vasquez AA;Lambregts-Rommelse N;Gill M;Anney RJ;Langely K;O'Donovan M;Williams N;Owen M;Thapar A;Kent L;Sergeant J;Roeyers H;Mick E;Biederman J;Doyle A;Smalley S;Loo S;Hakonarson H;Elia J;Todorov A;Miranda A;Mulas F;Ebstein RP;Rothenberger A;Banaschewski T;Oades RD;Sonuga-Barke E;McGough J;Nisenbaum L;Middleton F;Hu X;Nelson S;Psychiatric GWAS Consortium: ADHD Subgroup
通讯作者：
Psychiatric GWAS Consortium: ADHD Subgroup
影响因子：
--
作者：
Kuntsi, Jonna;Wood, Alexis C.;Asherson, Philip
通讯作者：
Asherson, Philip
影响因子：
9.8
作者：
Huang, B. E.;Lin, D. Y.
通讯作者：
Lin, D. Y.