Convergence of projections from the rat hippocampal formation, medial geniculate and basal forebrain onto single amygdaloid neurons: an in vivo extra- and intracellular electrophysiological study.
Convergence of projections from the rat hippocampal formation, medial geniculate and basal forebrain onto single amygdaloid neurons: an in vivo extra- and intracellular electrophysiological study.
复制标题
大鼠海马结构、内侧膝状体和基底前脑的投影收敛到单个杏仁核神经元：一项体内细胞外和细胞内电生理学研究。
DOI：
10.1016/0006-8993(92)91425-e
复制
发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Finch,DM
中科院分区：
文献类型：
--
作者：
Mello,LE;Tan,AM;Finch,DM
我们记录了额外的和细胞内的反应，从大鼠杏仁核神经元在体内的海马结构（齿状回，海马区CA 3和CA 4，内嗅皮层，下托复合体）电刺激后;内侧膝状体;和基底前脑（斜角带，腹侧苍白球，嗅结节，核丘脑，终纹床核，外侧视前区，无名质）。刺激海马结构诱发IPSP或EPSP-IPSP序列，其中IPSP的阈值低于EPSP。杏仁核中候选抑制性神经元的记录表明，海马结构的兴奋性传入既接触杏仁核抑制性神经元，也接触主神经元（前馈抑制），并且抑制性神经元具有较低的激活阈值。内侧膝状体刺激也诱发EPSP-IPSP序列。与这些结果形成鲜明对比的是，基底前脑结构的刺激诱发杏仁核神经元的短潜伏期IPSPs。这为基底前脑直接抑制杏仁核提供了第一个生理学证据。基底前脑刺激也诱发杏仁核神经元EPSP-IPSP序列。单个杏仁核神经元对海马结构、基底前脑和内侧膝状体的刺激可以显示出反应，表明来自这些区域的突触输入会聚到单个杏仁核细胞上。这些发现提供了关于杏仁核传入神经突触组织的进一步信息，并表明单个杏仁核神经元在这些不同来源的输入的突触整合中发挥作用。
We recorded extra- and intracellular responses from rat amygdaloid neurons in vivo after electrical stimulation of the hippocampal formation (dentate gyrus, hippocampal fields CA3 and CA4, entorhinal cortex, subicular complex); medial geniculate; and basal forebrain (diagonal band, ventral pallidum, olfactory tubercle, nucleus accumbens, bed nucleus of stria terminalis, lateral preoptic area, substantia innominata). Stimulation of hippocampal formation structures evoked IPSPs or EPSP-IPSP sequences in which the IPSP had a lower threshold than the EPSP. Recordings from candidate inhibitory neurons in the amygdala indicated that excitatory afferents from the hippocampal formation contact both amygdaloid inhibitory and principal neurons (feedforward inhibition), and that the inhibitory neurons have a lower threshold of activation. Medial geniculate stimulation also evoked EPSP-IPSP sequences. In marked contrast to these results, stimulation of basal forebrain structures evoked short latency IPSPs in amygdaloid neurons. This provides the first physiological evidence for direct inhibition of the amygdala by the basal forebrain. Basal forebrain stimulation also evoked EPSP-IPSP sequences in amygdaloid neurons. Individual amygdaloid neurons could show responses to stimulation of the hippocampal formation, basal forebrain, and medial geniculate, indicating that synaptic input from these areas converges onto single amygdaloid cells. The findings provide further information about the synaptic organization of afferents to the amygdala, and indicate that single amygdaloid neurons play a role in the synaptic integration of input from these diverse sources.