Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
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DOI：
10.1016/j.schres.2006.11.006
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发表时间：
2007-02-01
影响因子：
4.5
通讯作者：
Taylor, Eric A.
中科院分区：
文献类型：
--
作者：
Laurens, Kristin R.;Hodgins, Sheilagh;Taylor, Eric A.
需要进行前瞻性纵向调查来确定导致精神分裂症的因果过程。然而，目前还没有经济有效的方法来识别有患精神分裂症谱系障碍风险的儿童：尽管有精神分裂症家族史与患谱系障碍的风险升高相关，但大多数精神分裂症患者没有患病的亲属。本研究旨在测试筛查 9 至 12 岁儿童社区样本的可行性，以确定是否经历过先前研究中确定的精神分裂症三联症的假定前因，包括：（1）言语和/或运动发育迟缓或问题； (2) 社交、情感或行为问题； (3) 类似精神病的经历（PLE）。 548 名儿童和 264 名护理人员完成了问卷调查。 9.2%的男孩和4.1%的女孩表现出三联征。 58.9% 的儿童表示有过一次或多次 PLE 的“一定经历”。结果表明，对社区儿童样本进行问卷筛查，以寻找精神分裂症谱系障碍的假定前因是可行的。识别的准确性只能通过后续研究来确定。 (c) 2006 Elsevier B.V. 保留所有权利。
Prospective longitudinal investigations are needed to identify causal processes leading to schizophrenia. However, there is presently no cost-effective way to identify children who are at risk of developing schizophrenia spectrum disorders: Although having a family history of schizophrenia is associated with elevated risk for developing spectrum disorders, the majority of individuals with schizophrenia do not have an afflicted relative. The present study aimed to test the feasibility of screening a community sample of children, aged 9 to 12 years, to identify children who experienced a triad of putative antecedents of schizophrenia that had been identified from previous research, including: (1) speech and/or motor development lags or problems; (2) social, emotional, or behavioural problems; and (3) psychotic-like-experiences (PLEs). 548 children and 264 caregivers completed questionnaires. 9.2% of boys and 4.1% of girls displayed the triad of antecedents. 58.9% of the children reported "certain experience" of one or more PLEs. The results suggest that questionnaire screening of community samples of children for the putative antecedents of schizophrenia spectrum disorders is feasible. Accuracy of identification will only be established by follow-up studies. (c) 2006 Elsevier B.V. All rights reserved.