Recent malignant testicular tumor trend in Japan, a country with an aging population: a large-scale study of 2012?2015 hospital-based cancer registry data
Recent malignant testicular tumor trend in Japan, a country with an aging population: a large-scale study of 2012?2015 hospital-based cancer registry data
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人口老龄化国家日本近年来的恶性睾丸肿瘤趋势：2012年至2015年医院癌症登记数据的大规模研究
DOI：
10.1093/jjco/hyaa110
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发表时间：
2020
影响因子：
2.4
通讯作者：
Nishiyama Hiroyuki
中科院分区：
文献类型：
--
作者：
Kojo Kosuke;Kawai Koji;Kawahara Takashi;Kimura Tomokazu;Kandori Shuya;Nagumo Yoshiyuki;Nitta Satoshi;Kojima Takahiro;Okuyama Ayako;Higashi Takahiro;Nishiyama Hiroyuki
据估计，日本国家医院癌症登记数据库覆盖了所有新发癌症病例的约67%。使用这个数据库，我们分析了最近诊断的睾丸malignancy.MethodsWe的特点获得了2012-2015年诊断的6510例成人睾丸恶性肿瘤患者的数据。患者年龄，组织学诊断和睾丸生殖细胞肿瘤医院护理volumes.ResultsThe最常见的组织学分布是睾丸恶性肿瘤（60.3%的所有睾丸恶性肿瘤），其次是非睾丸恶性肿瘤（24.1%）和弥漫性大B细胞淋巴瘤（13.1%）。睾丸生殖细胞肿瘤患者的中位和平均年龄分别为38岁和39.8岁。年龄分布在30-40岁达到高峰，然后是40-50岁。大约18%的睾丸生殖细胞肿瘤患者年龄≥50岁。弥漫性大B细胞淋巴瘤患者的年龄高峰在70-80岁（平均67.7岁）。当分析仅限于在参与医院接受第一疗程癌症治疗的睾丸生殖细胞肿瘤患者时，睾丸生殖细胞肿瘤治疗量≥20的高容量医院数量限制为61家（占治疗≥1例睾丸生殖细胞肿瘤患者的605家医院的10.0%）。然而，当将治疗期间更换医院或治疗完成后复发的患者一起分析时，高流量医院的数量增加到104家（占612家医院的17.0%）。年龄较大的睾丸生殖细胞肿瘤患者和弥漫性大B细胞淋巴瘤患者的比例高于以前的想法。造成这一趋势的原因尚不清楚，但在一个人口超老龄化的国家，必须解决本文所确定的趋势。
ObjectiveJapan’s national database of hospital-based cancer registries is estimated to cover ~67% of all new cancer cases. Using this database, we analyzed the characteristics of the recently diagnosed testicular malignancy.MethodsWe obtained data for 6510 adult testicular malignancy patients diagnosed in 2012–2015. The distributions of patient ages, histological diagnoses and testicular germ cell tumor hospital care volumes were determined.ResultsThe most common histology was seminoma (60.3% of all testicular malignancies), followed by non-seminoma (24.1%) and diffuse large B-cell lymphoma (13.1%). The median and mean ages of the testicular germ cell tumor patients were high at 38 and 39.8 years, respectively. The age distribution peaked at 30–40 years, followed by 40–50 years. Approximately 18% of testicular germ cell tumor patients were ≥50 years. The ages of the diffuse large B-cell lymphoma patients peaked at 70–80 years (mean 67.7 years). When the analysis was limited to the testicular germ cell tumor patients who received first-course cancer treatment at the participating hospitals, the number of high-volume hospitals with ≥20 testicular germ cell tumor care volume was limited to 61 (10.0% of the 605 hospitals that treated ≥1 testicular germ cell tumor patient). However, when the patients who changed hospitals during treatment or relapsed after treatment completion were analyzed together, the number of high-volume hospitals increased to 104 (17.0% of 612 hospitals).ConclusionThe testicular germ cell tumor patients’ mean age was nearly 40 years. The proportions of older testicular germ cell tumor patients and diffuse large B-cell lymphoma patients were higher than previously thought. The reasons for this trend are unknown, but it is important to address the trend identified herein in a country with a super-aging population.