The immunogenicity and impact on nasopharyngeal carriage of fewer doses of conjugate pneumococcal vaccine immunization schedule
The immunogenicity and impact on nasopharyngeal carriage of fewer doses of conjugate pneumococcal vaccine immunization schedule
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DOI：
10.1016/j.vaccine.2011.01.098
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发表时间：
2011-04-05
期刊：
影响因子：
5.5
通讯作者：
Adegbola, Richard A.
中科院分区：
文献类型：
--
作者：
Ota, Martin O.;Akinsola, Adebayo;Adegbola, Richard A.
研究了小剂量肺炎球菌结合疫苗（PCV 7）继以肺炎球菌多糖疫苗（PPV）加强免疫的免疫原性和对携带的影响。684名婴儿被随机分配到三个组中的一个，在2至4个月龄之间接受一次（A）、两次（B）或三次（C）剂量的PCV 7，在10个月龄时接受PPV。在初次接种后，针对PCV 7血清型组合的> 0.35 mu/ml的保护性抗体滴度随着PCV 7剂量的数量而显著增加，44%对77%对94%（p < 0.001），并且与调理吞噬指数正相关，但与肺炎球菌的鼻咽携带负相关。抗体反应和肺炎球菌携带组之间的差异减少后，与PPV的加强，这意味着一个或两个剂量的PCV 7，与PPV的加强剂量的管理可能会降低对IPD在资源贫乏的国家的幼儿保护的成本。(C)2011爱思唯尔有限公司保留所有权利。
The immunogenicity and impact on carriage of fewer doses of pneumococcal conjugate vaccine (PCV7) followed by booster with pneumococcal polysaccharide vaccine (PPV) were investigated. 684 infants were assigned randomly to one of the three groups that received one (A), two (B) or three (C) doses of PCV7 between 2 and 4 months of age, plus PPV at 10 months. Following primary vaccination protective antibody titers of > 0.35 mu/ml against the PCV7 serotypes combined increased significantly with the number of PCV7 doses, 44% vs. 77% vs. 94% (p < 0.001), and correlated positively with the opsonophagocytic indices, but negatively with nasopharyngeal carriage of pneumococcus. The differences in antibody responses and pneumococcal carriage between the groups diminished following booster with PPV, implying that administration of one or two doses of PCV7, with a booster dose of PPV might lower the cost of protection against IPD in young children in resource poor countries. (C) 2011 Elsevier Ltd. All rights reserved.