The gut microbiota modulates host energy and lipid metabolism in mice
The gut microbiota modulates host energy and lipid metabolism in mice
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DOI：
10.1194/jlr.m002774
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发表时间：
2010-05-01
影响因子：
6.5
通讯作者：
Backhed, Fredrik
中科院分区：
文献类型：
--
作者：
Velagapudi, Vidya R.;Hezaveh, Rahil;Backhed, Fredrik
肠道微生物区系最近被确定为可能促进代谢性疾病的环境因素。为了研究肠道微生物区系对宿主能量和脂质代谢的影响，我们比较了常规饲养(conv-R)和无菌饲养(conv-R)小鼠的血清代谢组和血清、脂肪组织和肝脏的脂质体。Conv-R小鼠血清代谢产物丙酮酸、柠檬酸、延胡索酸和苹果酸水平升高，胆固醇和脂肪酸水平降低。我们还表明，微生物区系改变了血清、脂肪组织和肝脏中的一些脂质物种，其中对甘油三酯和磷脂酰胆碱的影响最大。Conv-R组小鼠血清甘油三酯水平较低，而脂肪组织和肝脏甘油三酯水平较高，与脂质清除量增加一致。我们的发现表明，肠道微生物区系同时影响宿主的能量和脂肪代谢，并突出了它在代谢性疾病发展中的作用。-Velagapudi，V.R.，R.Hezaveh，C.S.Reigstad，P.Gopalacharyulu，L.Yetukuri，S.伊斯拉姆，J.Felin，R.Perkins，J.Boren，M.Oresic和F.Backhed。肠道微生物区系调节宿主的能量和脂肪代谢。J.Lipid Res.2010年。51：1101-1112。
The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increased levels of energy metabolites, e. g., pyruvic acid, citric acid, fumaric acid, and malic acid, while levels of cholesterol and fatty acids were reduced. We also showed that the microbiota modified a number of lipid species in the serum, adipose tissue, and liver, with its greatest effect on triglyceride and phosphatidylcholine species. Triglyceride levels were lower in serum but higher in adipose tissue and liver of CONV-R mice, consistent with increased lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.-Velagapudi, V. R., R. Hezaveh, C. S. Reigstad, P. Gopalacharyulu, L. Yetukuri, S. Islam, J. Felin, R. Perkins, J. Boren, M. Oresic, and F. Backhed. The gut microbiota modulates host energy and lipid metabolism in mice. J. Lipid Res. 2010. 51: 1101-1112.