Changes in resting and walking energy expenditure and walking speed during pregnancy in obese women
Changes in resting and walking energy expenditure and walking speed during pregnancy in obese women
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DOI：
10.3945/ajcn.110.009399
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发表时间：
2011-09-01
影响因子：
7.1
通讯作者：
Callaway, Leonie K.
中科院分区：
文献类型：
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作者：
Byrne, Nuala M.;Groves, Ainsley M.;Callaway, Leonie K.
背景资料：据报告，怀孕期间营养不良妇女的能量保存过程是提供支持胎儿发育所需能量的公认战略。怀孕前肥胖的女性可以说有足够的脂肪储存来支持怀孕的能量需求，而不需要激发能量保存机制。目的：我们检验了肥胖女性会表现出行为适应[即，自选步行（SSW）速度降低]但不会表现出代谢补偿[即，妊娠期间静息代谢率（RMR）或步行代谢成本的降低。设计：RMR，SSW速度，步行代谢成本，测量了23名年龄为31 ± 4岁、体重指数（kg/m2）为33.6 ± 2.5（平均值±标准差）的妇女在妊娠15周和30周时的体重指数和人体测量学变量。RMR还测量了2个队列的非妊娠对照组的年龄，体重和身高的怀孕队列在15（n = 23）和30（n = 23）wk.Results匹配：Geolithic体重增加变化很大（11.3 +/- 5.4公斤），和52%的妇女获得更多的体重比推荐。RMR显著增加，平均增加177 6 176 kcal/d（11 +/- 12%; P < 0.0001）;然而，组内变异性较大。步行代谢成本和SSW速度均显著降低（P < 0.01）。而RMR增加>80%的队列，步行的净氧成本下降，在相同比例的women.Conclusion：虽然RMR的增加是大于体重增加的解释，证据的行为和生物补偿的代谢成本的步行观察肥胖妇女在怀孕期间。该试验在澳大利亚临床试验注册处注册为ACTRN 012606000271505。美国临床营养杂志2011;94：819-30。
Background: Energy-conserving processes reported in undernourished women during pregnancy are a recognized strategy for providing the energy required to support fetal development. Women who are obese before conceiving arguably have sufficient fat stores to support the energy demands of pregnancy without the need to provoke energy-conserving mechanisms.Objective: We tested the hypothesis that obese women would show behavioral adaptation [ie, a decrease in self-selected walking (SSW) speed] but not metabolic compensation [ie, a decrease in resting metabolic rate (RMR) or the metabolic cost of walking] during gestation.Design: RMR, SSW speed, metabolic cost of walking, and anthropometric variables were measured in 23 women aged 31 +/- 4 y with a BMI (in kg/m(2)) of 33.6 +/- 2.5 (mean +/- SD) at similar to 15 and 30 wk of gestation. RMR was also measured in 2 cohorts of nonpregnant control subjects matched for the age, weight, and height of the pregnant cohort at 15 (n = 23) and 30 (n = 23) wk.Results: Gestational weight gain varied widely (11.3 +/- 5.4 kg), and 52% of the women gained more weight than is recommended. RMR increased significantly by an average of 177 6 176 kcal/d (11 +/- 12%; P < 0.0001); however, the within-group variability was large. Both the metabolic cost of walking and SSW speed decreased significantly (P < 0.01). Whereas RMR increased in >80% of the cohort, the net oxygen cost of walking decreased in the same proportion of women.Conclusion: Although the increase in RMR was greater than that explained by weight gain, evidence of both behavioral and biological compensation in the metabolic cost of walking was observed in obese women during gestation. The trial is registered with the Australian Clinical Trials Registry as ACTRN012606000271505. Am J Clin Nutr 2011;94:819-30.