Cellulases and beyond: the first 70 years of the enzyme producer Trichoderma reesei.
Cellulases and beyond: the first 70 years of the enzyme producer Trichoderma reesei.
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DOI：
10.1186/s12934-016-0507-6
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发表时间：
2016-06-10
影响因子：
6.4
通讯作者：
Seiboth B
中科院分区：
文献类型：
--
作者：
Bischof RH;Ramoni J;Seiboth B
70多年前，丝状子囊菌里氏木霉在所罗门群岛上被分离，这是由于其能够降解含有纤维素的织物并在其上茁壮成长。这种依赖于其分泌的纤维素酶的特性现在被几个行业利用。最显着的是在使用T. reesei酶糖化来自可再生植物生物质的木质纤维素，以生产生物基燃料和化学品。本文综述了T. reesei作为生物精炼酶的主要生产宿主，并讨论了菌株工程的新兴趋势。最近还提出里氏木霉作为能够将生物聚合物底物直接转化为所需产物的综合生物加工生物。因此，我们通过回顾T. reesei。
More than 70 years ago, the filamentous ascomycete Trichoderma reesei was isolated on the Solomon Islands due to its ability to degrade and thrive on cellulose containing fabrics. This trait that relies on its secreted cellulases is nowadays exploited by several industries. Most prominently in biorefineries which use T. reesei enzymes to saccharify lignocellulose from renewable plant biomass in order to produce biobased fuels and chemicals. In this review we summarize important milestones of the development of T. reesei as the leading production host for biorefinery enzymes, and discuss emerging trends in strain engineering. Trichoderma reesei has very recently also been proposed as a consolidated bioprocessing organism capable of direct conversion of biopolymeric substrates to desired products. We therefore cover this topic by reviewing novel approaches in metabolic engineering of T. reesei.