Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
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DOI：
10.1161/circulationaha.104.483628
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发表时间：
2005-06-28
期刊：
影响因子：
37.8
通讯作者：
Newman, A
中科院分区：
文献类型：
--
作者：
Sutton-Tyrrell, K;Najjar, SS;Newman, A
背景-衰老导致血管硬化和压力波沿主动脉传播时速度的增加。在临床人群中，主动脉脉搏波速度（aPWV）增加与死亡率相关，但与一般人群无关。本研究的目的是确定aPWV是否与社区居住的老年人样本中的总死亡率和心血管（CV）死亡率以及CV事件相关。方法和结果- aPWV在基线时测量来自健康、衰老和身体组成（健康ABC）研究的2488名参与者。生命状态，死亡原因和冠心病（CHD），中风，充血性心力衰竭的医疗记录确定。在4.6年的时间里，有265人死亡，其中111人死于心血管疾病。有341例CHD事件、94例卒中事件和181例充血性心力衰竭病例。由于第一个和第二个aPWV四分位数之间的阈值效应，结果按四分位数显示。较高的aPWV与总死亡率（aPWV四分位数2、3和4与1的相对风险分别为1.5、1.6和1.7; P = 0.019）和心血管死亡率（aPWV四分位数2、3和4与1的相对风险分别为2.1、3.0和2.3; P = 0.004）相关。aPWV四分位数也与CHD（P = 0.007）和卒中（P = 0.001）显著相关。在调整了年龄、性别、种族、收缩压、已知的心血管疾病和其他与events.Conclusions相关的变量后，这些相关性仍然存在-在一般健康的社区居住老年人中，aPWV（动脉僵硬度的标志物）与较高的心血管死亡率、CHD和卒中相关。
Background - Aging results in vascular stiffening and an increase in the velocity of the pressure wave as it travels down the aorta. Increased aortic pulse wave velocity ( aPWV) has been associated with mortality in clinical but not general populations. The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular ( CV) mortality and CV events in a community- dwelling sample of older adults.Methods and Results - aPWV was measured at baseline in 2488 participants from the Health, Aging and Body Composition ( Health ABC) study. Vital status, cause of death and coronary heart disease ( CHD), stroke, and congestive heart failure were determined from medical records. Over 4.6 years, 265 deaths occurred, 111 as a result of cardiovascular causes. There were 341 CHD events, 94 stroke events, and 181 cases of congestive heart failure. Results are presented by quartiles because of a threshold effect between the first and second aPWV quartiles. Higher aPWV was associated with both total mortality ( relative risk, 1.5, 1.6, and 1.7 for aPWV quartiles 2, 3, and 4 versus 1; P = 0.019) and cardiovascular mortality ( relative risk, 2.1, 3.0, and 2.3 for quartiles 2, 3, and 4 versus 1; P = 0.004). aPWV quartile was also significantly associated with CHD ( P = 0.007) and stroke ( P = 0.001). These associations remained after adjustment for age, gender, race, systolic blood pressure, known CV disease, and other variables related to events.Conclusions - Among generally healthy, community- dwelling older adults, aPWV, a marker of arterial stiffness, is associated with higher CV mortality, CHD, and stroke.