Effects of fractionated doses of ionizing radiation on colonic motor activity.
Effects of fractionated doses of ionizing radiation on colonic motor activity.
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DOI：
10.1152/ajpgi.1992.263.4.g518
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发表时间：
1992-10
期刊：
影响因子：
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通讯作者：
M. Otterson;Sushil K. Sarna;S. Leming;J. Moulder;J. Fink
中科院分区：
文献类型：
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作者：
M. Otterson;Sushil K. Sarna;S. Leming;J. Moulder;J. Fink
在五只清醒的狗身上研究了分段照射对结肠运动的影响。植入七个结肠和两个回肠应变计传感器。对照记录后，每周间隔 3 次给予 250 cGy 的腹部剂量，连续三周（总剂量 2,250 cGy）。辐射完成后继续记录 3 周。在对照状态下，结肠巨大迁移性收缩 (GMC) 的发生频率为 0.15 +/- 0.05 次收缩/小时。这些收缩中只有一次 (8.3%) 起源于小肠并传播到结肠。腹部野照射显着增加结肠 GMC 的发生率，达到 0.51 +/- 0.11 次收缩/小时 (P < 0.05)。 54% 的 GMC 起源于小肠。在辐射计划期间，GMC 有 7 次与爆发性腹泻有关。辐射并没有改变结肠迁移运动复合体的频率，但中段和远端结肠收缩状态的平均持续时间减少。早在第二次放射剂量时就出现腹泻。结肠的病理变化与运动活动相关。停止辐射暴露后，小肠和结肠 GMC 都恢复到控制频率。腹部照射显着改变了结肠的收缩活动。这些变化与腹部绞痛和腹泻有关。
The colonic motor effects of fractionated irradiation were studied in five conscious dogs. Seven colonic and two ileal strain gauge transducers were implanted. After control recordings, an abdominal dose of 250 cGy was administered three times a week on alternate days for three successive weeks (total dose 2,250 cGy). Recordings were then continued for 3 wk after the completion of radiation. Colonic giant migrating contractions (GMCs) occurred at a frequency of 0.15 +/- 0.05 contractions/h in the control state. Only one of these contractions (8.3%) originated in the small bowel and propagated into the colon. Abdominal field irradiation significantly increased the incidence of colonic GMCs to 0.51 +/- 0.11 contractions/h (P < 0.05). Fifty-four percent of GMCs originated in the small intestine. GMCs during the radiation schedule were associated with explosive diarrhea on seven occasions. Irradiation did not alter the frequency of colonic migrating motor complexes, but the mean duration of contractile states decreased in the middle and distal colon. Diarrhea occurred as early as the second dose of radiation. Pathological changes in the colon were correlated with motor activity. Both small intestinal and colonic GMCs reverted to control frequencies after cessation of radiation exposure. Abdominal irradiation significantly altered the contractile activity of the colon. These changes are associated with abdominal cramping and diarrhea.