Bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
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DOI：
10.1016/j.jneuroim.2008.06.038
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发表时间：
2008-10-15
影响因子：
3.3
通讯作者：
Tuohy VK
中科院分区：
文献类型：
--
作者：
Altuntas CZ;Daneshgari F;Liu G;Fabiyi A;Kavran M;Johnson JM;Gulen MF;Jaini R;Li X;Frenkl TL;Tuohy VK
绝大多数多发性硬化症（MS）患者会出现膀胱控制问题，包括尿急、尿失禁、尿频和尿潴留。超过60%的MS患者表现出逼尿肌-括约肌协同失调，这是一种异常，其特征在于由于尿道括约肌和膀胱逼尿肌的不协调收缩而导致的尿流出阻塞。在目前的研究中，我们检查了膀胱功能的雌性SWXJ小鼠不同定义的神经功能障碍水平诱导实验性自身免疫性脑脊髓炎（EAE），广泛用于MS研究的中枢神经系统炎症的动物模型。我们发现，EAE小鼠发展严重的膀胱功能障碍，其特征是排尿频率显著增加，每次排尿的尿量显著减少。此外，我们发现膀胱异常的严重程度在EAE小鼠的临床EAE和神经功能障碍的严重程度直接相关。我们的研究是第一个显示和表征排尿异常的EAE小鼠，从而提供了一个最有用的模型系统，了解和治疗神经源性膀胱。
The vast majority of patients with multiple sclerosis (MS) develop bladder control problems including urgency to urinate, urinary incontinence, frequency of urination, and retention of urine. Over 60% of MS patients show detrusor-sphincter dyssynergia, an abnormality characterized by obstruction of urinary outflow as a result of discoordinated contraction of the urethral sphincter muscle and the bladder detrusor muscle. In the current study we examined bladder function in female SWXJ mice with different defined levels of neurological impairment following induction of experimental autoimmune encephalomyelitis (EAE), an animal model of central nervous system inflammation widely used in MS research. We found that EAE mice develop profound bladder dysfunction characterized by significantly increased micturition frequencies and significantly decreased urine output per micturition. Moreover, we found that the severity of bladder abnormalities in EAE mice was directly related to the severity of clinical EAE and neurologic disability. Our study is the first to show and characterize micturition abnormalities in EAE mice thereby providing a most useful model system for understanding and treating neurogenic bladder.
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影响因子：
2.1
作者：
Blok, BFM
通讯作者：
Blok, BFM
影响因子：
16.8
作者：
Steinman, L;Zamvil, SS
通讯作者：
Zamvil, SS
影响因子：
14.5
作者：
Athwal, BS;Berkley, KJ;Fowler, CJ
通讯作者：
Fowler, CJ
影响因子：
14.5
作者：
Blok, BFM;Sturms, LM;Holstege, G
通讯作者：
Holstege, G
影响因子：
6.6
作者：
BLAIVAS, JG;BARBALIAS, GA
通讯作者：
BARBALIAS, GA