Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia
Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia
复制标题
哺乳动物椎前神经节非胆碱能传递的脑啡肽调节
DOI：
10.1016/0006-8993(82)90211-6
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发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
N. Dun
中科院分区：
文献类型：
--
作者：
Z. Jiang;M. A. Simmons;N. Dun
在离体肠系膜下神经节的神经元中引起的非胆碱能兴奋电位被Met-和Leu-脑啡肽的浴应用抑制，并被纳洛酮或纳洛酮增强。外源性应用假定的递质P物质引起的膜去极化没有明显的影响，无论是脑啡肽（Enk）或阿片拮抗剂。我们的研究结果表明，非胆碱能兴奋性传输，这可能是由P物质介导的椎前神经节调制突触前内源性释放的Enk的方式，可能类似于这两种肽在脊髓之间的相互作用。
The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.