Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain.
Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain.
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DOI：
10.1097/j.pain.0000000000000799
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发表时间：
2017-04
期刊：
影响因子：
7.4
通讯作者：
Mantyh PW
中科院分区：
文献类型：
--
作者：
Majuta LA;Guedon JG;Mitchell SAT;Ossipov MH;Mantyh PW
全膝关节置换术（TKA）和全髋关节置换术（THA）是缓解骨关节炎疼痛的两种最常见和最成功的手术干预。控制术后疼痛对于患者充分参与所需的物理治疗至关重要，这是有效的术后膝关节康复的最有影响力的因素。目前，阿片类药物是治疗骨科手术后疼痛（包括TKA/THA疼痛）的主要药物。最近，阿片类药物的疗效、依赖性、过量和死亡等问题使临床医生和研究人员对使用阿片类药物治疗非恶性骨骼疼痛更加挑剔。在本报告中，评估了使用抗神经生长因子（抗NGF）单克隆抗体的非阿片类药物治疗在小鼠模型中增加手术膝关节自发活动的能力，该模型由小鼠股骨的股骨转子沟钻孔和取芯引起骨科手术疼痛。使用自动活动盒在20小时的白天/夜晚时间段内连续评估水平活动和速度以及垂直直立，以努力减少观察者偏差并在小鼠最活跃时捕获夜间活动。在矫形手术后的第1天和第3天，自发活动和垂直直立显著减少;抗神经生长因子显着减弱了这种下降。目前的数据表明，在关节/整形外科手术的啮齿动物模型中，抗NGF改善了肢体使用，因此抗NGF可能有助于控制整形外科手术（如TKA/THA）后的疼痛。
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are two of the most common and successful surgical interventions to relieve osteoarthritis pain. Control of postoperative pain is critical for patients to fully participate in the required physical therapy which is the most influential factor in effective postoperative knee rehabilitation. Currently opiates are a mainstay for managing postoperative orthopedic surgery pain including TKA/THA pain. Recently, issues including efficacy, dependence, overdose and death from opiates have made clinicians and researchers more critical of use of opioids for treating non-malignant skeletal pain. In the present report, a non-opiate therapy using a monoclonal antibody raised against nerve growth factor (anti-NGF) was assessed for its ability to increase the spontaneous activity of the operated knee joint in a mouse model of orthopedic surgery pain induced by drilling and coring the trochlear groove of the mouse femur. Horizontal activity & velocity and vertical rearing were continually assessed over a 20 hour day/night period using automated activity boxes in an effort to reduce observer bias and capture night activity when the mice are most active. At days 1 and 3 post-orthopedic surgery there was a marked reduction in spontaneous activity and vertical rearing; anti-NGF significantly attenuated this decline. The present data suggests that anti-NGF improves limb use in a rodent model of joint/orthopedic surgery and as such anti-NGF may be useful in controlling pain following orthopedic surgeries such as TKA/THA.