A single-step fabrication approach for development of antimicrobial surfaces
A single-step fabrication approach for development of antimicrobial surfaces
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DOI：
10.1016/j.jmatprotec.2019.04.012
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发表时间：
2019-09-01
影响因子：
6.3
通讯作者：
Ding, Fei
中科院分区：
文献类型：
--
作者：
Cai, Yukui;Luo, Xichun;Ding, Fei
近年来，医疗保健相关感染的发病率不断上升，抗生素的过度使用导致了对抗菌涂层医疗设备的高需求。银纳米粒子(AgNPs)因其广为人知的抗菌性能而引起人们极大的关注。然而，目前的AgNPs的物理和化学合成方法成本高、耗时长，而且不环保。本文首次提出了一种新的一步法制备抗菌AgNPs涂层微结构的方法，称为StruCoat，该方法通过减法激光烧蚀和加法化学沉积相结合的方法来制备抗菌AgNPs涂层微结构。这种新方法可以为手术工具和植入物等医疗设备提供抗菌微结构银涂层。在用纳秒脉冲激光制备的316 L不锈钢试件上演示了StruCoat方法，同时利用雾化器同时产生微滴的硝酸银溶液将AgNPs分解并包覆在这些微结构上。实验结果表明，硝酸银的摩尔浓度为50 mmol，在14W加工条件下喷射到不锈钢上是化学分解硝酸银溶液液滴的最佳操作条件，得到了平均尺寸为480 nm的AgNPs。此外，对经StruCoat处理的不锈钢表面的材料显微组织的研究表明，材料的晶粒度显著减小(与常规激光加工相比减少了81%)，这将有助于提高试件的断裂韧性和强度。抗菌测试还表明，StruCoat处理的样品具有良好的抗菌性能，与光滑表面相比，金黄色葡萄球菌的表面附着减少了86.2%。总体而言，这项研究表明StruCoat是一种潜在的制备抗菌表面的方法。
In recent years, the increasing incidence of healthcare-associated infections and overuse of antibiotics have led to high demand for antimicrobial-coated medical devices. Silver nanoparticles (AgNPs) have attracted tremendous attention as a subject of investigation due to their well-known antibacterial properties. However, current physical and chemical synthesis methods for AgNPs are costly, time-consuming and not eco-friendly. For the first time, this paper proposes a novel single-step fabrication approach, named StruCoat, to generate antimicrobial AgNPs coated microstructures through hybridizing subtractive laser ablation and additive chemical deposition processes. This new approach can offer antimicrobial micro-structured silver coatings for medical devices such as surgical tools and implants. The StruCoat approach is demonstrated on 316 L stainless steel specimens structured by using nanosecond pulsed laser, while AgNPs are decomposed and coated on these microstructures from the micro drops of silver nitrate solution simultaneously generated by an atomizer. According to the experimental results, silver nitrate with a molarity of 50 mmol and jet to the stainless steel machined at 14 W are the best-operating conditions for chemical decomposition of drops of silver nitrate solution in this research and results in AgNPs with a mean size of 480 nm. Moreover, an investigation of the material microstructures of stainless steel surfaces processed by StruCoat shows significant reduction of material grain size (81% reduction compared to that processed by normal laser machining) which will help improve the fracture toughness and strength of the specimen. Antimicrobial testing also demonstrated that specimens processed by StruCoat exhibited excellent antibacterial properties with 86.2% reduction in the surface attachment of Staphylococcus aureus compared to the smooth surface. Overall, this study has shown StruCoat is a potential approach to prepare antimicrobial surfaces.