POWER AND SAMPLE-SIZE CALCULATIONS FOR CLINICAL-TRIALS OF MYOFASCIAL PAIN OF JAW MUSCLES
POWER AND SAMPLE-SIZE CALCULATIONS FOR CLINICAL-TRIALS OF MYOFASCIAL PAIN OF JAW MUSCLES
复制标题
DOI：
10.1177/00220345910700020401
复制
发表时间：
1991-02-01
影响因子：
7.6
通讯作者：
LUND, JP
中科院分区：
文献类型：
--
作者：
DAO, TTT;LAVIGNE, GJ;LUND, JP
当计划进行临床试验时，必须估计出检测组间显著差异所需的受试者的大致数量。样本大小的计算为研究者提供了这一信息。本文讨论了结果测量的选择，并描述了用于估计研究所需受试者数量的步骤，该研究比较了下颌肌肉慢性肌筋膜疼痛患者的治疗方法。对所选变量，即受试者在视觉模拟量表上的疼痛评分，估计受试者内部和受试者之间的差异。然后通过预处理均值和总体标准差计算各组之间的理论差异的样本量（Cohen, 1977）。这一分析的结果可供其他研究人员在计划涉及这类患者的研究时使用。
When a clinical trial is planned, the approximate number of subjects needed for significant differences between/among groups to be detected must be estimated. Sample-size calculations provide the investigator with this information.This paper discusses the choice of outcome measures and describes the steps used to estimate the numbers of subjects necessary for a study that compares treatments for patients with chronic myofascial pain of jaw muscles. Within- and between-subject variances were estimated for the chosen variables, the subjects' pain ratings on visual analogue scales. Sample sizes were then calculated for theoretical differences between groups by pre-treatment means and overall standard deviations (Cohen, 1977).The results of this analysis can be used by other researchers when planning studies involving these types of patients.