Cobalt(III) catalyzed C-8 selective C-H and C-O coupling of quinoline N-oxide with internal alkynes via C-H activation and oxygen atom transfer
Cobalt(III) catalyzed C-8 selective C-H and C-O coupling of quinoline N-oxide with internal alkynes via C-H activation and oxygen atom transfer
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DOI：
10.1039/c5cc08736h
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Sundararaju, Basker
中科院分区：
文献类型：
--
作者：
Barsu, Nagaraju;Sen, Malay;Sundararaju, Basker
报道了一种有效的、可放大的、原子经济的、区域选择性的空气稳定的Cp*Co（III）催化的C-H和C-O偶联反应，该反应通过喹啉N-氧化物和内炔的C-H活化/氧原子转移反应进行。与现有文献相比，首次使用钴催化剂并使用N-氧化物作为无痕导向基团见证了这种催化转化。所开发的合成方法是直接的，并具有各种官能团的公差，包括杂环。
An efficient, scalable, atom-economical, regio-selective air stable Cp*Co(III) catalyzed C-H and C-O coupling via a C-H activation/oxygen atom transfer reaction of quinoline N-oxide and an internal alkyne is reported. Such a catalytic transformation is witnessed for the first time with a cobalt catalyst and using N-oxide as a traceless directing group, in contrast to the existing literature. The developed synthetic methodology is straightforward and possesses various functional group tolerances, including heterocycles.