SARS-CoV-2 infection in Spanish children with chronic kidney pathologies
SARS-CoV-2 infection in Spanish children with chronic kidney pathologies
复制标题
DOI：
10.1007/s00467-020-04597-1
复制
发表时间：
2020-05-20
影响因子：
3
通讯作者：
Perez-Beltran, V
中科院分区：
文献类型：
--
作者：
Melgosa, M.;Madrid, A.;Perez-Beltran, V
背景关于2019冠状病毒病（COVID-19）在患有基础慢性肾脏病变的儿童中的信息很少。病例报告从2020年3月至4月15日，西班牙有16名患有慢性肾脏疾病的儿童被诊断患有COVID-19。其中，6例患有终末期肾病（ESKD）（3例移植受者和3例慢性血液透析）。所有患者症状的严重程度均为轻度，几乎没有放射学受累。3名患者无症状。发热和上呼吸道症状是最常见的发现。3例患者的基础肾小球滤过率恶化;然而，通过补液和药物剂量调整迅速恢复。在2名被诊断为激素依赖性肾病综合征的患者中，COVID-19引发了疾病复发。没有人需要氧气治疗，7人可以作为门诊病人进行管理。结论COVID-19疾病在患有基础慢性肾脏病变的儿童中似乎具有相似的临床病程，即使在免疫抑制的情况下，也与同龄健康儿童相似;但是，必须特别注意液体管理和药物剂量调整。
Background There is little information about Coronavirus Disease 2019 (COVID-19) in children with underlying chronic renal pathologies. Cases report From March until April 15, 2020, 16 children with chronic renal pathologies were diagnosed with COVID-19 in Spain. Of these, 6 had end-stage kidney disease (ESKD) (3 transplant recipients and 3 on chronic hemodialysis). The severity of symptoms was mild in all the patients, with little radiological involvement. Three patients were asymptomatic. Fever and upper respiratory symptoms were the most frequent findings. Basal glomerular filtration worsened in 3 patients; however, recovery was rapidly achieved with rehydration and drug dose adjustment. In 2 patients diagnosed with steroid-dependent nephrotic syndrome, COVID-19 provoked a disease relapse. None required oxygen therapy, and 7 could be managed as outpatients. Conclusions COVID-19 disease appears to have a similar clinical course in children with underlying chronic renal pathologies, even in immunosuppressed cases, as in healthy children of the same age; however, special attention must be paid to fluid management and drug dose adjustment.