Ultrastructural alterations of the cortical epithelial cells of the irradiated and recovering rat thymus
Ultrastructural alterations of the cortical epithelial cells of the irradiated and recovering rat thymus
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DOI：
10.1679/aohc.68.205
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Fukumoto, T
中科院分区：
文献类型：
--
作者：
Arudchelvan, Y;Tokuda, N;Fukumoto, T
为了了解胸腺皮质上皮细胞（CTECs）在t淋巴细胞发育中的作用，我们在超微结构水平上分析了辐照（6Gy）后恢复的大鼠胸腺。ctec的形态学改变在恢复后的第3 ~ 5天最为显著，此时在ctec附近观察到增殖的胸腺细胞。辐照后ctec的变化中最显著的发现是细胞质空泡化，颗粒和膜质含量增加。颗粒含量为松散聚集结构或细密分散的颗粒和致密体。膜质内容物以各种形式出现，包括泡状、管状和不规则的膜质结构和髓鞘图。上述特征是ctec分泌活性增加的高功能状态的特征，提示其在照射后恢复过程中皮质胸腺细胞的再生和成熟中起重要作用。
To understand the roles of cortical thymic epithelial cells (CTECs) in T-lymphocyte development, we analyzed rat thymi recovering from irradiation (6Gy), at the ultrastructural level. The morphological alterations in the CTECs were most prominent during the third to fifth day of recovery, when proliferating thymocytes were observed in the vicinity of the CTECs. The most striking finding among the alterations in the CTECs after irradiation was a cytoplasmic vacuolization with an increased amount of granular and membranous content. The granular content was observed as loosely aggregated structures or finely dispersed granules and dense bodies. The membranous content appeared in various forms including vesicular, tubular, and irregular membranous structures and myelin figures. The above features are characteristic of the hyperfunctional state of CTECs with increased secretion activities, which suggests their important roles in the repopulation and maturation of the cortical thymocytes during recovery after irradiation.