SERUM-LIPOPROTEIN IN ACTIVE RHEUMATOID-ARTHRITIS AND OTHER CHRONIC INFLAMMATORY ARTHRITIDES .2. EFFECTS OF ANTIINFLAMMATORY AND DISEASE-MODIFYING DRUG-TREATMENT
SERUM-LIPOPROTEIN IN ACTIVE RHEUMATOID-ARTHRITIS AND OTHER CHRONIC INFLAMMATORY ARTHRITIDES .2. EFFECTS OF ANTIINFLAMMATORY AND DISEASE-MODIFYING DRUG-TREATMENT
复制标题
DOI：
10.1001/archinte.147.11.1917
复制
发表时间：
1987-11-01
影响因子：
--
通讯作者：
VESSBY, B
中科院分区：
文献类型：
--
作者：
SVENSON, KLG;LITHELL, H;VESSBY, B
前瞻性分析了33例未经治疗的活动型慢性炎症性关节炎患者在不同的抗炎和改善疾病的药物方案中的血脂和脂蛋白模式。在治疗前，脂蛋白模式的特征是所有脂蛋白组分中胆固醇浓度低，极低密度脂蛋白组分和高密度脂蛋白组分中甘油三酯浓度低。在泼尼松龙联合硫唑嘌呤或环磷酰胺(n=10)治疗期间，疾病活动度降低，脂蛋白模式正常化；在一小部分患者(n=4)单独使用强的松龙治疗，而非类固醇抗炎药物治疗(n=9)对脂蛋白模式和急性期反应物测定的炎症活性均无明显影响。长期应用青霉胺(n=4)和氯喹(n=6)可使疾病临床缓解，炎症活动度降低。在青霉胺治疗期间，脂蛋白浓度开始恢复到正常值。相比之下，氯喹治疗组脂蛋白脂浓度的变化更加明显，即血清中胆固醇和甘油三酯浓度以及极低密度脂蛋白分数降低。
Serum lipids and lipoprotein patterns were prospectively analyzed in 33 previously untreated patients with active chronic inflammatory arthritides during different anti-inflammatory and disease-modifying drug regimens. Before treatment the lipoprotein pattern was characterized by low cholesterol concentrations in all lipoprotein fractions and low triglyceride concentrations in the very-low-density lipoprotein fraction as well as in the high-density lipoprotein fraction. During treatment with prednisolone combined with azathioprine or cyclophosphamide (n = 10), a reduction of the disease activity was achieved and the lipoprotein pattern was normalized; similar results were noted in a small group of patients (n = 4) treated with prednisolone alone while nonsteroidal antiinflammatory drug therapy (n = 9) neither significantly affected the lipoprotein pattern nor the inflammatory activity measured by the acute-phase reactants. The long-term treatment with penicillamine (n = 4) and chloroquine (n = 6) induced both a clinical remission of the disease and a reduction of the inflammatory activity. The lipoprotein concentrations started to reverse to the normal values during penicillamine treatment. In contrast, in the chloroquine-treated group the alterations in lipoprotein lipid concentrations were further pronounced, ie, the cholesterol and triglyceride concentrations in serum and the very-low-density lipoprotein fraction decreased.